1196473-37-6

Basic information

• Product Name: benzo[c][1,2]oxaborole-1,6(3H)-diol
• Synonyms: benzo[c][1,2]oxaborole-1,6(3H)-diol;1-hydroxy-3H-2,1-benzoxaborol-6-ol;6-hydroxyl-1,3-dihydro-1-hydroxy-2,1-benzoxaborole;1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-ol;Benzo[c][1,2]oxaborole-1,6(3H);EOS-60533
• CAS NO: 1196473-37-6
• Molecular Formula: C₇H₇BO₃
• Molecular Weight: 149.93968
• Mol File: 1196473-37-6.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: benzo[c][1,2]oxaborole-1,6(3H)-diol(CAS DataBase Reference)
• NIST Chemistry Reference: benzo[c][1,2]oxaborole-1,6(3H)-diol(1196473-37-6)
• EPA Substance Registry System: benzo[c][1,2]oxaborole-1,6(3H)-diol(1196473-37-6)

Safety Data

• Hazardous Substances Data: 1196473-37-6(Hazardous Substances Data)

Usage

General Description

Benzo[c][1,2]oxaborole-1,6(3H)-diol is a chemical compound that is a derivative of oxaborole. It is known for its unique structure, consisting of a six-membered ring containing oxygen and boron atoms. benzo[c][1,2]oxaborole-1,6(3H)-diol has shown potential applications in pharmaceuticals, particularly in the development of new antimalarial and antifungal drugs. Its structure allows for interactions with specific biological targets, making it a valuable molecule for drug design. Benzo[c][1,2]oxaborole-1,6(3H)-diol has also demonstrated activity against resistant strains of malaria and fungi, making it an important candidate for the development of new therapeutic agents.

Upstream product

• 1222010-47-0 6-benzyloxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole 
• 947163-26-0 6-methoxybenzo[c][1,2]oxaborol-1(3H)-ol 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 1196474-59-5 4-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 
• 229027-89-8 (2-bromo-4-fluorophenyl)methanol 
• 43192-31-0 2-bromo-4-methoxybenzaldehyde 
• 50-00-0 formaldehyd 
• 87199-18-6 3-hydroxyphenylboronic acid 
• 1222010-85-6 2-((4-(benzyloxy)-2-bromobenzyl)oxy)tetrahydro-2H-pyran 
• 1222010-84-5 2-((2-bromo-4-fluorobenzyl)oxy)tetrahydro-2H-pyran 
• 197015-32-0 4-methoxy-2-trifluoromethanesulfonyloxybenzaldehyde 
• 59142-68-6 2-bromo-4-fluorobenzaldehyde 
• 1226773-36-9 (5-(benzyloxy)-2-formylphenyl)boronic acid 
• 1226773-35-8 C₁₆H₁₅BrO₃ 

Downstream Products

• 1222010-61-8 6-(4'-fluoro)benzyloxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole 
• 1222010-64-1 6-(2-nitrobenzyloxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole 
• 1222010-58-3 6-(2-fluorobenzyloxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole 
• 1222010-52-7 1,3-dihydro-1-hydroxy-2,2-benzoxaborol-6-yl N-phenylcarbamate 
• 1222010-55-0 1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl N-cyclohexylcarbamate 
• 1268390-23-3 6-(pyridin-2-ylmethoxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole 
• 1268390-40-4 ethyl [2-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yloxy)]-2-phenylacetate 
• 1268390-25-5 6-cyclohexylmethoxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole 
• 1196473-62-7 2-(1-hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-6-yloxy)-pyrimidine-5-carboxylic acid 
• 947163-26-0 6-methoxybenzo[c][1,2]oxaborol-1(3H)-ol 
• 1213786-71-0 C₁₄H₁₃BFNO₃*ClH 
• 1213786-76-5 C₁₄H₉BClNO₃ 
• 1426224-20-5 C₁₄H₁₁BClNO₄ 
• 1213786-72-1 C₁₄H₁₃BClNO₃*ClH 

Relevant articles and documents

Synthesis method of benzoxaborole

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of benzoxaborole. The synthesis method comprises the step of in an organic solvent, under the condition of a strong acid catalyst, carrying out dehydration condensation reaction on a compound shown in a formula (A) and a compound shown in a formula (B) to obtain a compound shown in a formula (C). The compounds shown in the formulas (A) and (B) and the reaction solvent in the raw materials for preparing the benzoxaborole by adopting the method are simple and easy to obtain; the reaction steps are simple, and the product can be obtained by only one step; the reaction atom economy is high, and the reaction conditions are mild; and the reaction is suitable for mass production.

BTK (Bruton's tyrosine kinase) inhibitors

The invention belongs to the field of medicinal chemistry and particularly relates to compounds shown as formula (I) in the description, medically acceptable salts of the compounds, a preparation method of the compounds and pharmaceutical composition containing the compounds. The invention further relates to an application of the compounds, the medically acceptable salts of the compounds and the pharmaceutical composition containing the compounds to treatment of BTK (Bruton's tyrosine kinase) related diseases.

BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS

This invention provides novel compounds of the following formula useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.