1196475-63-4

Upstream product

• 43192-33-2 4-bromo-2-methoxybenzaldehyde 
• 4463-42-7 benzyl boronic acid 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 1196475-62-3 4-benzyl-2-hydroxybenzaldehyde 

Downstream Products

• 1196475-43-0 4-benzyl-2-(4,4,5,5-tetramethyl-[1,3,2]dioxoborolan-2-yl)benzaldehyde 
• 947163-12-4 6-(benzyl)benzo[c][1,2]oxaborol-1(3H)-ol 
• 1196474-30-2 (6-benzyl-1-hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl)-acetic acid ethyl ester 
• 1196474-32-4 6-benzyl-3-methanesulfonylmethyl-3H-benzo[c]oxaborol-1-ol 
• 1196474-31-3 (6-Benzyl-1-hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl)-acetic acid 

Relevant academic research and scientific papers

Benzoxaborole-1-alcohol compound and preparation method and application thereof

The invention belongs to the field of bactericides, and particularly relates to a benzoxaborole-1-alcohol compound and a preparation method and application thereof. The benzoxaborole-1-alcohol compound has good bactericidal activity, can effectively control tomato early blight, wheat scab, rice sheath blight disease, strawberry gray mold, apple blotch, cucumber anthracnose and other crop diseases,can produce excellent antibacterial effects at low concentration, and shows good selectivity. The compound is used as a leucyl-tRNA synthetase inhibitor, the evolution difference of aminoacyl-tRNA synthetase of germs and eukaryotes is utilized, and the compound has very high safety to non-target organisms while killing the germs and can be used as a bactericide in agriculture.

BORON-CONTAINING SMALL MOLECULES

This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.

Discovery of novel benzoxaborole-based potent antitrypanosomal agents

We report the discovery of benzoxaborole antitrypanosomal agents and their structure?activity relationships on central linkage groups and different substitution patterns in the sulfur-linked series. The compounds showed in vitro growth inhibition IC5