1196490-98-8Relevant articles and documents
Heptamethine cyanine small molecule for multi-mode treatment of hypoxia tumors as well as preparation method and application of heptamethine cyanine small molecule
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, (2021/11/26)
The invention relates to a heptamethine cyanine small molecule for multi-mode treatment of hypoxia tumors as well as a preparation method and application of the heptamethine cyanine small molecule. The small molecule consists of a mitochondrial targeting indole heptamethine chain, a butyl sulfonate side chain and a 2-nitroimidazole N-alkyl side chain. Under the induction of infrared light, the photodynamic effect, the photothermal effect and the radiotherapy sensitization effect are good, and the growth of tumors can be obviously inhibited. The small molecule is low in preparation cost, has near-infrared imaging and tumor targeted accumulation characteristics, can distinguish tumors and boundaries, and can be used for precise phototherapy and radiotherapy of tumors under the guidance of near-infrared imaging.