1196541-47-5

Basic information

• Product Name: (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide
• Synonyms: GDC0575 (ARRY-575,RG7441);Cyclopropanecarboxamide, N-[4-[(3R)-3-amino-1-piperidinyl]-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl]-;EOS-61380;ARRY-575;ARRY-575, RG7741;GDC-0575 (ARRY-575, RG7741)
• CAS NO: 1196541-47-5
• Molecular Formula: C₁₆H₂₀BrN₅O
• Molecular Weight: 378.2669
• Mol File: 1196541-47-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.619±0.06 g/cm3(Predicted)
• PKA: 14.25±0.40(Predicted)
• CAS DataBase Reference: (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide(1196541-47-5)
• EPA Substance Registry System: (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide(1196541-47-5)

Safety Data

• Hazardous Substances Data: 1196541-47-5(Hazardous Substances Data)

Usage

General Description

The chemical "(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide" is a cyclopropane derivative that contains a 1H-pyrrolo[2,3-b]pyridine ring system. It also contains an aminopiperidine moiety and a bromine atom. (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide is a chiral molecule, with the (R) configuration. It may have potential pharmaceutical applications due to its structural features and biological activity. The presence of the cyclopropane and pyrrolopyridine moieties could make it of interest for drug discovery and development programs targeting various biological pathways. Further research and study are necessary to fully understand the properties and potential applications of this chemical compound.

Upstream product

• 1196508-04-9 (R)-5-bromo-4-(3-(tert-butoxycarbonylamino)piperidin-1-yl)-3-(cyclopropanecarboxamido)-1H-pyrrolo[2,3-b]pyridine 
• 1477532-48-1 5-bromo-4-chloro-3-nitro-1H-pyrrolo[2,3-b]pyridine 
• 309956-78-3 (R)-piperidin-3-ylcarbamic acid tert-butyl ester 

Relevant articles and documents

An Efficient Through-Process for Chk1 Kinase Inhibitor GDC-0575

We report an efficient route to prepare Chk1 kinase inhibitor GDC-0575 from 5-bromo-4-chloro-3-nitro-7-azaindole featuring a sequence of nucleophilic aromatic substitution, hydrogenative nitro-reduction, and a robust, high-yielding end-game involving deprotection-crystallization steps. The developed route was demonstrated on 10 kg scale in 30% overall yield to provide the target API in >99.8 A % HPLC purity.

PROCESS FOR PREPARING A COMPOUND

The invention provides processes of preparation thereof useful in the preparation of compounds that can be used as CHK1 inhibitors.