119662-55-4Relevant academic research and scientific papers
Antimalarial, antitrypanosomal, and antileishmanial activities and cytotoxicity of bis(9-amino-6-chloro-2- methoxyacridines): Influence of the linker
Girault, Sophie,Grellier, Philippe,Berecibar, Amaya,Maes, Louis,Mouray, Elisabeth,Lemière, Pascal,Debreu, Marie-Ange,Davioud-Charvet, Elisabeth,Sergheraert, Christian
, p. 2646 - 2654 (2000)
Forty bis(9-amino-6-chloro-2-methoxyacridines), in which acridine moieties are joined by alkanediamines, polyamines, or polyamines substituted by a side chain, were synthesized and tested for their in vitro activity upon the erythrocytic stage of Plasmodi
Synthesis of monomeric and dimeric acridine compounds as potential therapeutics in Alzheimer and prion diseases
Csuk, Rene,Barthel, Alexander,Raschke, Christian,Kluge, Ralph,Stroehl, Dieter,Trieschmann, Lothar,Boehm, Gerald
experimental part, p. 699 - 709 (2010/06/19)
Starting from substituted 9-chloroacridines, a series of quinacrine and spacered dimeric acridine compounds was prepared. Their ability to interrupt the protein association of prion- and Alzheimer-specific proteins and Ab peptides was explored using a fast screening system based on FACS analysis. The bis-acridines displayed a higher activity than the corresponding monomers. Among these derivatives, best results were obtained with the 2,4-dimethoxy-6-nitro compound 7h for Aβ-peptides and the 2-methoxy-6-nitro compound 7f for PrP.
