1196681-44-3 Usage
General Description
BMS 777607, also known as "Bristol-Myers Squibb Compound 777607", is a potent inhibitor of the Met family tyrosine kinases, with a particular focus on the c-Met receptor also known as the hepatocyte growth factor receptor (HGFR). This receptor plays a crucial role in cancer progression and metastasis, hence the interest in developing inhibitors like BMS 777607. It's been studied in the context of various cancer types, including non-small cell lung cancer, gastric cancer, and head and neck squamous cell carcinoma. Its inhibitory activity disrupts cellular growth and proliferation signals, thereby suppressing tumour growth and metastasis.
Check Digit Verification of cas no
The CAS Registry Mumber 1196681-44-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,6,6,8 and 1 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1196681-44:
(9*1)+(8*1)+(7*9)+(6*6)+(5*6)+(4*8)+(3*1)+(2*4)+(1*4)=193
193 % 10 = 3
So 1196681-44-3 is a valid CAS Registry Number.
1196681-44-3Relevant articles and documents
PHOSPHONATE CONJUGATES AND USES THEREOF
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, (2020/07/31)
Phosphonate conjugates, preferably, bisphosphonate conjugates; methods of inhibiting Ron receptor tyrosine kinase and methods of treatment of bone destruction due to cancer or other conditions utilizing the provided phosphonate conjugates.
PYRIDINONE COMPOUNDS
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Page/Page column 9, (2008/12/05)
The invention is directed to pyridinone compounds useful for modulating Met kinase, having the following structure: and is further directed to pharmaceutical compositions comprising the compound; and methods for treating proliferative diseases, such as ca
