1196714-47-2Relevant academic research and scientific papers
Four-component reactions toward fused heterocyclic rings
Airiau, Etienne,Girard, Nicolas,Mann, Andre,Salvadori, Jessica,Taddei, Maurizio
, p. 5314 - 5317 (2009)
A multicomponent reaction between H2, CO, an unsaturated carboxylic acid derivative, and binucleophiles has been discovered. This process represents a combination of diversity-oriented synthesis and multicomponent reactions including amidation and hydroformylation, followed by nucleophilic addition to an N-acyliminium ion allowing the generation of six new bonds. Using π-nucleophiles, the sequence turns into a multicomponent Pictet-Spengler reaction.
