1196734-99-2Relevant academic research and scientific papers
Selective synthesis of DOPA and DOPA peptides by native and immobilized tyrosinase in organic solvent
Botta, Giorgia,Delfino, Michela,Guazzaroni, Melissa,Crestini, Claudia,Onofri, Silvano,Saladino, Raffaele
, p. 325 - 330 (2013/08/23)
3,4-Dihydroxyphenylalanine (DOPA)-containing peptides and proteins provide attractive design paradigms for pharmaceutical applications and engineering of synthetic polymers. An efficient and selective route to DOPA peptides by oxidation of ltyrosine deriv
A novel and efficient synthesis of DOPA and DOPA peptides by oxidation of tyrosine residues with IBX
Bernini, Roberta,Barontini, Maurizio,Crisante, Fernanda,Ginnasi, Maria Cristina,Saladino, Raffaele
scheme or table, p. 6519 - 6521 (2011/02/23)
An efficient route to 3,4-dihydroxylphenylalanine (DOPA) and DOPA peptides was described by oxidation of L-tyrosine and L-tyrosine derivatives with 2-iodoxybenzoic acid (IBX). DOPA was obtained after an situ reduction of the corresponding ortho-quinone with sodium dithionite. Oxidation reactions proceeded in good yields and high chemo- and regio-selectivity. The chirality of the DOPA residue was retained under the reaction conditions. The efficiency and the selectivity of the reaction were successfully tested using recyclable polymer-supported IBX.
