1196852-00-2Relevant academic research and scientific papers
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors
Gangjee, Aleem,Li, Wei,Lin, Lu,Zeng, Yibin,Ihnat, Michael,Warnke, Linda A.,Green, Dixy W.,Cody, Vivian,Pace, Jim,Queener, Sherry F.
experimental part, p. 7324 - 7336 (2010/03/30)
To optimize dual receptor tyrosine kinase (RTK) and dihydrofolate reductase (DHFR) inhibition, the E- and Z-isomers of 5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamines (1a and 1b) were separated by HPLC and the X-ray crystal structu
