1196870-90-2Relevant academic research and scientific papers
Studies of asymmetric induction in the synthesis of dinucleoside phosphorothioates from 2-oxo-1,3,2-dithiaphospholane nucleoside derivatives
Olesiak, Magdalena,Okruszek, Andrzej
experimental part, p. 1548 - 1560 (2010/03/31)
The nucleoside derivatives, containing at 3'-O or 5'-O-position 2-oxo-1,3,2-dithiaphospholane function were found to react in the presence of DBU with a hydroxyl group of appropriately protected nucleosides to yield, after deprotection, dinucleoside phosphorothioates in moderate yields. An asymmetric induction connected with the formation of new chiral phosphorothioate center has been examined.
