1196885-76-3Relevant academic research and scientific papers
Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists
Stocking, Emily M.,Aluisio, Leah,Atack, John R.,Bonaventure, Pascal,Carruthers, Nicholas I.,Dugovic, Christine,Everson, Anita,Fraser, Ian,Jiang, Xiaohui,Leung, Perry,Lord, Brian,Ly, Kiev S.,Morton, Kirsten L.,Nepomuceno, Diane,Shah, Chandravadan R.,Shelton, Jonathan,Soyode-Johnson, Akinola,Letavic, Michael A.
scheme or table, p. 2755 - 2760 (2010/09/09)
Pre-clinical characterization of novel substituted pyrrolidines that are high affinity histamine H3 receptor antagonists is described. These compounds efficiently penetrate the CNS and occupy the histamine H3 receptor in rat brain following oral administration. One compound, (2S,4R)-1-[2-(4-cyclobutyl-[1,4]diazepane-1-carbonyl)-4-(3-fluoro-phenoxy)-pyrrolidin-1-yl]-ethanone, was extensively profiled and shows promise as a potential clinical candidate.
SUBSTITUTED PYRROLIDINE AMIDES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
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, (2009/12/05)
Certain substituted pyrrolidine amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
