1196966-94-5Relevant articles and documents
1,3-Dipolar cycloaddition of nitrile imines with functionalized acetylenes: Regiocontrolled Sc(OTf)3-catalyzed synthesis of 4- and 5-substituted pyrazoles
Bonini, Bianca Flavia,Franchini, Mauro Comes,Gentili, Denis,Locatelli, Erika,Ricci, Alfredo
experimental part, p. 2328 - 2332 (2010/01/16)
1,3-Dipolar cycloaddition of C-aryl-N-aryl- and C-carboxymethyl-N-aryl- nitrile imines with functionalized acetylenes have been studied. Regioisomeric mixtures have been obtained with the 5-substituted pyrazole as the major cycloadduct. Under scandium triflate catalysis a reversal in the regiochemistry was observed, especially in the case of C-carboxymethyl-N-aryl-nitrile imines. Georg Thieme Verlag Stuttgart.