1196995-43-3

Basic information

• Product Name: 4,6-bis((E)-4-hydroxy-3-methoxystyryl)pyrimidine-2(1H)-thione
• Synonyms: 4,6-bis((E)-4-hydroxy-3-methoxystyryl)pyrimidine-2(1H)-thione
• CAS NO: 1196995-43-3
• Molecular Weight: 408.478
• Mol File: 1196995-43-3.mol

Chemical Properties

• CAS DataBase Reference: 4,6-bis((E)-4-hydroxy-3-methoxystyryl)pyrimidine-2(1H)-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-bis((E)-4-hydroxy-3-methoxystyryl)pyrimidine-2(1H)-thione(1196995-43-3)
• EPA Substance Registry System: 4,6-bis((E)-4-hydroxy-3-methoxystyryl)pyrimidine-2(1H)-thione(1196995-43-3)

Safety Data

• Hazardous Substances Data: 1196995-43-3(Hazardous Substances Data)

Upstream product

• 458-37-7 curcumin 
• 17356-08-0 thiourea 
• 147556-16-9 curcumin 

Relevant articles and documents

Conversion of Curcumin into heterocyclic compounds as potent anti-diabetic and anti-histamine agents

Potential biologically active derivatives of the curcumin were prepared by the cyclocondensation reaction cyclohexanone 2, imino pyrimidine 3, pyrmidinones 4, thiopyrimidine 6 and pyranone 5, 7 when treated with acetylacetone, guanidine, ureaethylcyanoacetate, thiourea and ethylacetoacetate, respectively. The structures of compounds (2–7) were elucidated by means of microanalysis as well as spectral measurements such as IR, 1H-NMR, MS. The anti-diabetic potential of curcumin derivatives were evaluated by assessing amylase inhibition assay, also inhibition of histamine release activity of curcumin derivatives were assessed by U937 human monocytes. The results for amylase inhibition activity revels that the curcumin inhibits α-amylase in a concentration dependent manner. Compounds 4 and 5 exhibited significant inhibitory activity against amylase enzyme and was comparable with that of acrabose. Also, compounds 5, 6 and 7 exhibited significant inhibitory activity against histamine. Our results concluded that curcumin pyrmidinones and pyranone derivatives have highly effects as anti-diabetic and anti-histamine activities.

In-silico designing, chemical synthesis, characterization and in-vitro assessment of antibacterial properties of some analogues of curcumin

In the present work two key regulator proteins, monomeric MipZ of Caulobacter vibrioides (similar to Pseudomonas aeruginosa) and Pyruvate kinase of Staphylococcus aureus were docked with curcumin, the wonder molecule from the spice turmeric and structures

Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers

Novel iminothiazinylbutadienols and divinylpyrimidinethiones were designed and synthesized as analogues of curcumin with its diketone moiety masked as a heterocyclic adduct with thiourea. The chemical stability of these novel heterocyclic compounds was improved as compared to curcumin. They exhibit longer half-lives and do not react with nucleophilic thiols under physiological conditions. In an ARE-luciferase reporter assay, some of these new curcumin analogues are more effective ARE activators than curcumin and isothiocyanates.