1197-28-0

Usage

Uses

Used in Pharmaceutical Industry:
4,6-Dichloro-2-propyl-pyrimidine is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agricultural Chemicals:
In the agricultural sector, 4,6-Dichloro-2-propyl-pyrimidine serves as an intermediate for the production of herbicides and fungicides. Its incorporation into these compounds helps in the control of weeds and fungi, thereby protecting crops.
Used in Organic Compounds Synthesis:
4,6-Dichloro-2-propyl-pyrimidine is used as a building block in the synthesis of other organic compounds. Its reactive nature makes it a valuable component in creating a variety of chemical products.
Safety Measures:
Given its powerful and reactive nature, 4,6-Dichloro-2-propyl-pyrimidine requires proper safety measures during handling and use in chemical reactions to prevent accidents and ensure the safety of personnel and the environment.

Upstream product

• 3603-18-7 2-propyl-1H-pyrimidine-4,6-dione 
• 98334-67-9 2-propyl-1H-pyrimidine-4,6-dione 

Downstream Products

• 98334-41-9 2-propyl-3H-pyrimidin-4-one 
• 100910-69-8 2-propyl-pyrimidin-4-ylamine 
• 114426-10-7 4,6-dimethoxy-2-propyl-pyrimidine 

Relevant academic research and scientific papers

'Green' synthesis of 2-substituted 6-hydroxy-[3H]-pyrimidin-4-ones and 4,6-dichloropyrimidines: Improved strategies and mechanistic study

An improved route to 2-substituted 6-hydroxy-[3H]-pyrimidin-4-ones 4 and to 2-substituted 4,6-dichloropyrimidines 5 is reported. Without using highly toxic reactants, compounds 4 can be prepared conveniently in a one pot synthesis on a one mol scale with average yields up to 80%. 4,6-Dichloropyrimidines 5, which are usually prepared in small quantities, are synthesized with average yields of 80%, using up to 80g of starting material. The mechanism of the chlorination of 4 is investigated computationally for the first time. The results suggest that the chlorination with phosphoryl chloride occurs in an alternating phosphorylation-chlorination manner (pathway 1) which is preferred over a sequence which starts with two phosphorylations. The investigated 4,6-dichloropyrimidines described herein form strong complexes with dichlorophosphoric acid but weak complexes with hydrochloric acid (generated during workup). These latter complexes explain the necessity of using aqueous sodium carbonate during the working up. In order to prevent possible formation of pyrimidinium salts between intermediates or the final dichloropyrimidines and unreacted hydroxypyrimidone, the latter could be deactivated with a strong acid such as dichlorophosphoric acid, thus allowing chlorination but prohibiting salt formation. Because of its general applicability to all nitrogen heterocycle chlorinations with phosphoryl chloride, the proposed route to dichloropyrimidines without solvent or side products, using less toxic reactants, is of general synthetic interest.