1197026-72-4Relevant academic research and scientific papers
A versatile approach to cis-5-substituted 4-hydroxy-2-pyrrolidinones: asymmetric synthesis of angiogenesis inhibitor streptopyrrolidine
Xiang, Shao-Hua,Yuan, Hong-Qiu,Huang, Pei-Qiang
experimental part, p. 2021 - 2026 (2010/02/28)
A concise, flexible, and highly diastereoselective approach to cis-5-alkyl-4-hydroxy-2-pyrrolidinones 1 is described. The key step is an ammonium acetate-assisted catalytic hydrogenation of the enamides 9, derived in two steps from malimides 6a,b as we ha
