119706-76-2

Basic information

• Product Name: (S)-2-((R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-{[(S)-2-((E)-(2S,6R,8S)-8-hydroxy-2,4,6-trimethyl-non-4-enoylamino)-propionyl]-methyl-amino}-propionylamino)-propionic acid
• CAS NO: 119706-76-2
• Molecular Weight: 726.824
• Mol File: 119706-76-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-((R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-{[(S)-2-((E)-(2S,6R,8S)-8-hydroxy-2,4,6-trimethyl-non-4-enoylamino)-propionyl]-methyl-amino}-propionylamino)-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-{[(S)-2-((E)-(2S,6R,8S)-8-hydroxy-2,4,6-trimethyl-non-4-enoylamino)-propionyl]-methyl-amino}-propionylamino)-propionic acid(119706-76-2)
• EPA Substance Registry System: (S)-2-((R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-{[(S)-2-((E)-(2S,6R,8S)-8-hydroxy-2,4,6-trimethyl-non-4-enoylamino)-propionyl]-methyl-amino}-propionylamino)-propionic acid(119706-76-2)

Safety Data

• Hazardous Substances Data: 119706-76-2(Hazardous Substances Data)

Upstream product

• 117289-84-6 (E)-(2S,6R,8S)-8-{[tert-butyl(dimethyl)silyl]oxy}-2,4,6-trimethylnon-4-enoic acid 
• 117405-40-0 (3S,4R,6S)-6-tert-butyldimethylsiloxy-3-hydroxy-2,4-dimethyl-1-heptene 
• 117289-82-4 6-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethyl-hept-1-en-3-ol 
• 127462-46-8 2-<(1'R,3'S)-3'-hydroxy-1'-methyl>butyl-1,3-dithiane 
• 127462-50-4 (S)-2-{(R)-2-[((S)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid tert-butyl ester 
• 127462-49-1 (S)-2-[((R)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid benzyl ester 
• 127462-48-0 O-tert-butyldimethylsilyl-N-Boc-N-methyl-D-tyrosine benzyl ester 
• 129439-64-1 (S)-2-[((R)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid 
• 127462-47-9 O-tert-butyldimethylsilyl-N-Boc-D-tyrosine benzyl ester 
• 129453-35-6 O-tert-butyldimethylsilyl-N-methyl-D-tyrosine benzyl ester 
• 117289-83-5 (3R,4R,6S)-6-tert-butyldimethylsiloxy-2,4-dimethyl-3-propanoyloxy-1-heptene 
• 129439-62-9 (4R,6S)-6-tert-butyldimethylsiloxy-2,4-dimethyl-1-hepten-3-one 
• 129439-61-8 2-<(1'R,3'S)-3'-tert-butyldimethylsiloxy-1'-methyl>butyl-1,3-dithiane 
• 117289-81-3 (2R,4S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-methylpentanal 

Downstream Products

• 108675-64-5 (+)-geodiamolide B 
• 119724-74-2 (E)-(3S,6R,9S,12S,16R,18S)-6-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-benzyl]-3,7,9,12,14,16,18-heptamethyl-1-oxa-4,7,10-triaza-cyclooctadec-14-ene-2,5,8,11-tetraone 

Relevant articles and documents

A TOTAL SYNTHESIS OF (+)-GEODIAMOLIDES A AND B, THE NOVEL CYCLODEPSIPEPTIDES

Diastereo-controlled total synthesis of (+)-geodiamolides A (1) and B (2) has been accomplished via a prior synthesis of the tetrapropionate-derived fragment 7 and of the halogenated N-methyltyrosyltripeptide 6, the latter involving direct halogenation of the tripeptide 5, and subsequent coupling of both fragments followed by the trichlorobenzoyl chloride-mediated macrolactonization, respectively.