1197170-01-6

Basic information

• Product Name: C₃₁H₃₉N₉O₃
• CAS NO: 1197170-01-6
• Molecular Weight: 585.709
• Mol File: 1197170-01-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₁H₃₉N₉O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₁H₃₉N₉O₃(1197170-01-6)
• EPA Substance Registry System: C₃₁H₃₉N₉O₃(1197170-01-6)

Safety Data

• Hazardous Substances Data: 1197170-01-6(Hazardous Substances Data)

Upstream product

• 67455-41-8 4-(piperazin-1-yl)aniline 

Relevant articles and documents

2-Arylureidophenyl-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)triazines as highly potent and selective ATP competitive mTOR inhibitors: Optimization of human microsomal stability

Isosteric replacement of one of the 3,5-ethylene-bridged morpholines in 2-arylureidophenyl-4,6-di(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)triazines led to significant improvements in human microsomal stability. 3-R-Me-morpholine and tetrahydropyran were identified as preferred isosteres for the bridged morpholine. Combination of tetrahydropyran substitution with an N-Me-piperazinophenylureido group led to 27, that selectively suppressed mTOR biomarkers in vivo and possessed excellent efficacy in a murine xenograft model.