1197196-66-9

Basic information

• Product Name: 2-chloro-6,7-dimethoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
• Synonyms: 2-chloro-6,7-dimethoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
• CAS NO: 1197196-66-9
• Molecular Weight: 336.821
• Mol File: 1197196-66-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-chloro-6,7-dimethoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6,7-dimethoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine(1197196-66-9)
• EPA Substance Registry System: 2-chloro-6,7-dimethoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine(1197196-66-9)

Safety Data

• Hazardous Substances Data: 1197196-66-9(Hazardous Substances Data)

Upstream product

• 41838-46-4 4-Amino-1-methylpiperidine 
• 27631-29-4 2-chloro-6,7-dimethoxy-3H-quinazolin-4-one 

Downstream Products

• 1197196-55-6 6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine 

Relevant articles and documents

Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a

SAR exploration of the 2,4-diamino-6,7-dimethoxyquinazoline template led to the discovery of 8 (UNC0224) as a potent and selective G9a inhibitor. A high resolution X-ray crystal structure of the G9a-8 complex, the first cocrystal structure of G9a with a small molecule inhibitor, was obtained. The cocrystal structure validated our binding hypothesis and will enable structure-based design of novel inhibitors. 8 is a useful tool for investigating the biology of G9a and its roles in chromatin remodeling.

Quinazoline hydroxamic acid derivative and preparation method and application thereof

The invention relates to a quinazoline hydroxamic acid derivative and a preparation method and application thereof. The structural formula of the quinazoline hydroxamic acid derivative is as shown informula I: Y is substituted or unsubstituted aliphatic hydrocarbon group or aromatic hydrocarbon group, R1 is a nitrogen-containing substituent group, and R2 and R3 are each independently hydrogen oran alkyl group. Researches show that the compound shown in the formula I has good inhibitory activity on histone methyltransferase and histone deacetylase, can effectively inhibit tumor cell proliferation, and can be used as a lead compound for research and development of antitumor drugs.

HISTONE DEACETYLASE AND HISTONE METHYLTRANSFERASE INHIBITORS AND METHODS OF MAKING AND USE OF THE SAME

The compounds of formula (I) are dual inhibitors of the enzymes histone deacetylases (HDACs) and histone methyltransferase G9a, both of which are key posttranslational enzymes in cancer development.