1197238-95-1

Basic information

• Product Name: 2-(2,5-DIFLUORO-PHENYL)-PYRROLIDINE, HYDROCHLORIDE
• Synonyms: 2-(2,5-DIFLUORO-PHENYL)-PYRROLIDINE, HYDROCHLORIDE
• CAS NO: 1197238-95-1
• Molecular Formula: C10H12ClF2N
• Molecular Weight: 219.66
• Mol File: 1197238-95-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(2,5-DIFLUORO-PHENYL)-PYRROLIDINE, HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,5-DIFLUORO-PHENYL)-PYRROLIDINE, HYDROCHLORIDE(1197238-95-1)
• EPA Substance Registry System: 2-(2,5-DIFLUORO-PHENYL)-PYRROLIDINE, HYDROCHLORIDE(1197238-95-1)

Safety Data

• Hazardous Substances Data: 1197238-95-1(Hazardous Substances Data)

Usage

General Description

2-(2,5-Difluoro-phenyl)-pyrrolidine, hydrochloride is a chemical compound that consists of a pyrrolidine ring with a 2,5-difluoro-phenyl group attached to it. The hydrochloride salt form of this compound makes it more stable and easier to handle in laboratory settings. It is commonly used in organic synthesis and pharmaceutical research as a building block for the creation of various drugs and other biologically active molecules. The presence of the difluoro-phenyl group makes it a valuable component for the development of potential drug candidates with specific biological activities. Overall, 2-(2,5-Difluoro-phenyl)-pyrrolidine, hydrochloride is an important chemical in the field of drug discovery and development.

Upstream product

• 1216260-42-2 4‐chloro‐1‐(2,5-difluorophenyl)butan-1-one 
• 1443538-30-4 (S,E)-N-(4-chloro-1-(2,5-difluorophenyl)butylidene)-2-methylpropane-2-sulfinamide 
• 1443538-31-5 (R)-1-((S)-tert-butylsulfinyl)-2-(2,5-difluorophenyl)pyrrolidine 
• 540-36-3 para-difluorobenzene 
• 871127-78-5 C₁₀H₈F₂O₃ 
• 399-94-0 2-bromo-1,4-difluorobenzene 
• 1218935-58-0 (R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate 

Downstream Products

• 1218935-59-1 (R)-(+)-2-(2,5-difluorophenyl)pyrrolidine 
• 1260840-74-1 5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((S)-2,3-dihydroxypropyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 1260846-28-3 (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 1260840-77-4 (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 1260845-57-5 ethyl (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 1260842-01-0 5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((S)-2,3-dihydroxypropoxy)pyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 1260846-92-1 5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)pyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 1260845-56-4 (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid 
• 1260840-05-8 (R)-N-tert-butyl-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 1260840-10-5 (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(3-methylpyridin-2-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 1443538-87-1 (R)-ethyl 5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate 
• 1443538-88-2 (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid 
• 1443536-91-1 (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide 
• 1443536-92-2 (R)-N-(tert-butylsulfonyl)-5-(2-(2, 5-difluorophenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3-carboxamide 

Relevant articles and documents

Synthesis method of -2-(2, 5-difluorophenyl) pyrrolidine hydrochloride

The invention discloses a synthetic method of 2-(2, 5-difluorophenyl) pyrrolidine hydrochloride, which belongs to the field of drug synthesis. P-difluorobenzene and succinic anhydride are used as rawmaterials and subjected to a Friedel-Crafts reaction to obtain an intermediate I, the intermediate I is reduced to obtain an intermediate II, the intermediate II is subjected to an esterification reaction to obtain an intermediate III, and finally, the intermediate III is subjected to cyclization and salification under the action of liquid ammonia to obtain the 2-(2, 5-difluorophenyl) pyrrolidinehydrochloride. The method has the advantages of mild reaction conditions, cheap and easily available raw materials, high yield and good product purity.

SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.