1197357-99-5

Upstream product

• 1945-84-2 2-ethynylpyridine 
• 107947-17-1 methyl 3-bromo-4-chlorobenzoate 

Downstream Products

• 1197358-00-1 4-chloro-3-(pyridin-2-ylethynyl)benzoic acid 
• 1197358-18-1 1-[4-chloro-3-(pyridin-2-ylethynyl)benzoyl]-4-pyridin-2-ylpiperazine 
• 1253291-15-4 2-[4-chloro-3-(pyridin-2-ylethynyl)benzoyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 1253291-13-2 2-[4-chloro-3-(pyridin-2-ylethynyl)benzoyl]isoindoline hydrochloride 

Relevant academic research and scientific papers

BISARYL ALKYNYLAMIDES AS NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 5 (MGLUR5)

Disclosed are compounds of Formula (I): pharmaceutical compositions containing compounds of Formula I, and the use of compounds of Formula (I) to treat diseases and disorders including schizophrenia, paranoia, depression, manic-depressive illness and anxiety wherein W1-W5, X1-X4, Y, Z1-Z5, m, n, p, and R1-R6 in Formula (I) are defined in the specification.

PIPERAZINE METABOTROPIC GLUTAMATE RECEPTOR 5 (MGLUR5) NEGATIVE ALLOSTERIC MODULATORS FOR ANXIETY/DEPRESSION

The present teachings relate to piperazine metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulators having Formula (I); wherein the constituent variables are as defined herein. The present teachings further relate to methods for the preparation of the compounds, and to methods for using the compounds for treatment of diseases and disorders including schizophrenia, paranoia, depression, manic-depressive illness and anxiety.