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1197376-85-4

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  • -Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride/cas:1197376-85-4/high quality

    Cas No: 1197376-85-4

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  • 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride

    Cas No: 1197376-85-4

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1197376-85-4 Usage

Description

INCB28060 Dihydrochloride is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.

Uses

INCB28060 dihydrochloride exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, INCB 28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.

Check Digit Verification of cas no

The CAS Registry Mumber 1197376-85-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,7,3,7 and 6 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1197376-85:
(9*1)+(8*1)+(7*9)+(6*7)+(5*3)+(4*7)+(3*6)+(2*8)+(1*5)=204
204 % 10 = 4
So 1197376-85-4 is a valid CAS Registry Number.

1197376-85-4Downstream Products

1197376-85-4Relevant articles and documents

PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 2-FLUORO-N-METHYL-4-[7-QUINOLIN-6-YL-METHYL)-IMIDAZO[1,2-B][1,2,4]TRIAZIN-2YL]BENZAMIDE

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, (2021/08/27)

The present invention relates to a novel chemical process for the synthesis of the compound 2- fluoro-N-methyl-4-[7-quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2yl]benzamide.

IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS

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Page/Page column 45, (2008/12/05)

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