1197398-05-2

Upstream product

• 1197398-13-2 C₁₂H₁₅FO₆ 
• 1197398-03-0 methyl (1R,2R,4S,5S,6R)-2-(acetyloxy)-6-fluoro-4-hydroxybicyclo[3.1.0]hexane-6-carboxylate 
• 1197398-02-9 methyl (1R,2R,4S,5S,6S)-6-fluoro-2,4-dihydroxybicyclo [3.1.0] hexane-6-carboxylate 
• 7129-41-1 6-oxabicyclo[3.1.0]hex-2-ene 
• 542-92-7 cyclopenta-1,3-diene 
• 852395-14-3 methyl fluoro[(1R,5R)-5-hydroxycyclopent-2-en-1-yl]acetate 
• 1197398-04-1 methyl (1R,2R,5S,6S)-2-(acetyloxy)-6-fluoro-4-oxobicyclo[3.1.0]hexane-6-carboxylate 
• 852395-27-8 (4S,5S)-2,2,7,7-tetramethyl-4,5-diphenyl-3,6-dioxa-2,7-disilaoctane 
• 852395-20-1 methyl (1R,2R,4S,5S,6R)-2-{[tert-butyl(dimethyl)silyl]oxy}-6-fluoro-4-hydroxybicyclo[3.1.0]hexane-6-carboxylate 
• 2325-10-2 (S,S)-hydrobenzoin 
• 77-73-6 bi(cyclopentadiene) 

Downstream Products

• 852395-25-6 methyl (1S,4R,4'S,5R,5'S,6S)-6-fluoro-4-hydroxy-4',5'-diphenylspiro[bicyclo[3.1.0]hexane-2,2'-[1,3]dioxolane]-6-carboxylate 

Relevant academic research and scientific papers

METHOD OF PRODUCING BICYCLO[3.1.0] HEXANE DERIVATIVE USING ENZYME

Production of a bicyclo[3.1.0]hexane derivative, useful as a metabotropic glutamate receptor modulator, becomes possible by a production method that includes converting a compound represented by Formula (II) into a compound represented by Formula (III) by reaction with an acyl group donor in the presence of a microorganism-derived enzyme, without using an expensive optically active trans hydroxy ester as a starting material and without employing a fluorination reaction requiring an ultralow temperature reaction. Furthermore, since asymmetric synthesis can be carried out in a stage closer to the final product, the production method is useful as a production method that can mass produce a bicyclo[3.1.0]hexane derivative.