119755-45-2Relevant academic research and scientific papers
Benzopyrans. Part 23. Nitrogen Heterocycles Fused with or Linked to 1-Benzopyran from 3-Acyl-2-methyl-1-benzopyran-4-one
Ghosh, Chandra, Kanta,Pal, Chandana,Maiti, Jharna,Sarkar, Manjusha
, p. 1489 - 1494 (2007/10/02)
The enamine (2), prepared from the title benzopyranone (1; R2=H,Me,and Ph) and dimethylformamide dimehylacetal, on treatment with ammonia and hydroxylamine gives the fused pyridine (5) and pyridine-2-oxide (10), respectively.Hydrazine, phenylhydrazine, and guanidine undergo initial 1,6-addition to the enamine (2) ultimately giving the pyrazoles (14) and (15), and the pyrimidine (17), respectively.The pyridinioacetamidate (11), prepared from the enamine (2; R2=Me and Ph) and acetohydrazide, thermolyses to the fused pyridine (5).A refluxing ethanolic solution of the enamine (2; R2=Me and Ph) with ethyl glycinate forms the ester (18) which on treatment with ethanolic sodium ethoxide produces the azepine(20).
