119755-63-4Relevant articles and documents
N,N-disubstituted aminomethyl benzofuran derivatives: Synthesis and preliminary binding evaluation
Boye, Sophie,Pfeiffer, Bruno,Renard, Pierre,Rettori, Marie-Claire,Guillaumet, Gerald,Viaud, Marie-Claude
, p. 335 - 341 (2007/10/03)
A series of new N-substituted 2,3-dihydro-2-aminomethyl-2H-1-benzofuran derivatives was prepared and evaluated for affinity at 5-HT(1A), 5-HT(2A), 5-HT(2C), 5-HT3, D2, and D3 receptors. Compound 9, 8-[4-[N-propyl-N-(7-hydroxy-2,3-dihydro-2H-1-benzofuran-2-yl)methyl]aminobutyl]-8-azaspiro[4,5]decane-7,9-dione, bound at 5-HT(1A) sites with nanomolar affinity (IC50=1.5nM) and high selectivity over 5-HT(2A), 5-HT(2C), 5-HT3, D2, and D3 receptors. Copyright (C) 1999 Elsevier Science Ltd.