119757-73-2

Basic information

• Product Name: TAUTOMYCETIN SOLUTION
• Synonyms: TAUTOMYCETIN SOLUTION;3-hydroxy-3-(4-methyl-2,5-dioxo-2,5-dihydro-furan-3-yl)propionic acid 16-ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxooctadeca-15,17-dienyl ester solution;(1R*,2S*)-16-Ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoicacidester
• CAS NO: 119757-73-2
• Molecular Formula: C33H50O10
• Molecular Weight: 606.7441
• Mol File: 119757-73-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 763.7°Cat760mmHg
• Flash Point: 233.9°C
• Appearance: colorless/
• Density: 1.148g/cm³
• Vapor Pressure: 6.37E-27mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: −20°C
• Solubility: DMSO: 10 mg/mL
• CAS DataBase Reference: TAUTOMYCETIN SOLUTION(CAS DataBase Reference)
• NIST Chemistry Reference: TAUTOMYCETIN SOLUTION(119757-73-2)
• EPA Substance Registry System: TAUTOMYCETIN SOLUTION(119757-73-2)

Safety Data

• Hazardous Substances Data: 119757-73-2(Hazardous Substances Data)

Usage

Uses

Tautomycetin induces apoptosis by inactivating Akt through a PP1-independent signaling pathway in human breast cancer cells. Tautomycin is closely related to another anhydride containing polyketide PP inhibitor called Tautomycetin which, in addition to being useful as a lead for cancer drug discovery, also is a very potent immunosuppressor.

Biological Activity

Potent activated T cell-specific immunosuppressor. Selectively inhibits PP1 over PP2 with IC 50 values of 1.6 and 62 nM respectively. Active in vivo .

InChI:InChI=1/C33H50O10/c1-9-24(10-2)15-25(34)14-19(4)13-18(3)11-12-26(35)21(6)28(37)16-27(36)20(5)23(8)42-30(39)17-29(38)31-22(7)32(40)43-33(31)41/h9,15,18-21,23,26-27,29,35-36,38H,1,10-14,16-17H2,2-8H3/b24-15-