119789-44-5Relevant articles and documents
Investigation into the functional impact of the vancomycin C-ring aryl chloride
Pinchman, Joseph R.,Boger, Dale L.
, p. 4817 - 4819 (2013)
A vancomycin aglycon analogue that possesses a reduced C-ring and an intact E-ring chloride was prepared and its antimicrobial activity towards Staphylococcus aureus and binding affinity to model cell wall ligands were established. Comparison of the derivative with a series of vancomycin aglycon analogues that possess and lack the chloro substituents on the aryl C- and E-rings defines the impact and further refines the role the C-ring chloride plays in promoting both target binding affinity and binding selectivity for d-Ala-d-Ala and its impact on antimicrobial activity.
Total Syntheses of Vancomycin and Eremomycin Aglycons
Evans, David A.,Wood, Michael R.,Wesley Trotter,Richardson, Timothy I.,Barrow, James C.,Katz, Jeffrey L.
, p. 2700 - 2704 (2007/10/03)
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