1198-63-6

Basic information

• Product Name: 1,3-DIAMINO-2,4,5,6-TETRAFLUOROBENZENE
• Synonyms: DTFB;2,4,5,6-tetrafluoro-3-benzenediamine;Tetrafluoro-1,3-phenylenediamine;1,3-Diaminotetrafluorobenzene 85%;1,3-Diaminotetrafluorobenzene85%;TETRAFLUORO-META-PHENYLENEDIAMINE;2,4,5,6-Tetrafluoro-1,3-benzenediamine;(3-amino-2,4,5,6-tetrafluoro-phenyl)amine
• CAS NO: 1198-63-6
• Molecular Formula: C₆H₄F₄N₂
• Molecular Weight: 180.1
• EINECS: 214-836-0
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 1198-63-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 131-132°C
• Boiling Point: 223.416 °C at 760 mmHg
• Flash Point: 95.935 °C
• Appearance: /
• Density: 1,35 g/cm3
• Vapor Pressure: 0.0964mmHg at 25°C
• Refractive Index: 1.538
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.15±0.10(Predicted)
• CAS DataBase Reference: 1,3-DIAMINO-2,4,5,6-TETRAFLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DIAMINO-2,4,5,6-TETRAFLUOROBENZENE(1198-63-6)
• EPA Substance Registry System: 1,3-DIAMINO-2,4,5,6-TETRAFLUOROBENZENE(1198-63-6)

Safety Data

• Hazard Codes: Xi
• TSCA: T
• HazardClass: IRRITANT-HARMFUL
• Hazardous Substances Data: 1198-63-6(Hazardous Substances Data)

Usage

Uses

1,3-Diaminotetrafluorobenzene is used for carcinogenicity and toxicity testing for aromatic amines. Also in the prepartion of tissue adhesive composition, e.g. (use of polyurethane adhesive in closing incisions).

InChI:InChI=1/C6H4F4N2/c7-1-2(8)5(11)4(10)6(12)3(1)9/h11-12H2

Upstream product

• 392-56-3 Hexafluorobenzene 
• 771-60-8 2,3,4,5,6-pentafluoroaniline 
• 2247-97-4 3-N₂H₃-C₆F₄NH₂ 
• 1551-54-8 1-aminoheptafluoro-3-iminocyclohexene 
• 16325-35-2 tetrafluoro-1,3-phenylene diisocyanate 

Downstream Products

• 2241-48-7 2,4,5,6-tetrafluoro-1,3-bis(dimethylamino)benzene 
• 16325-35-2 tetrafluoro-1,3-phenylene diisocyanate 
• 321182-37-0 2,4,5-trifluoro-1,3-phenylenediamine 
• 25170-73-4 2,5-difluoro-1,3-phenylenediamine 
• 92057-37-9 Bis-N.N--tetrafluor-m-phenylen-diamin 

Relevant articles and documents

Catalytic and noncatalytic ammonolysis of chloropentafluorobenzene

Ammonolysis of chloropentafluorobenzene both in the presence and in the absence of copper(I) salt results mainly in replacement of the para-and ortho-fluorine atoms with respect to chlorine rather than replacement of the chlorine atom. Ammonolysis of 4-chloro-2,3,5,6-tetrafluoroaniline and 2-chloro-3,4,5,6-tetrafluoroaniline in the absence of copper(I) salt yields exclusively the corresponding fluorine substitution products, whereas in the presence of copper(I) salt the chlorine atom is replaced. Successive ammonolysis of chloropentafluorobenzene in the presence of copper catalyst along these two paths was put into the basis of a new method for preparation of 2,3,5,6-tetrafluoro-1,4-phenylenediamine. * This study was financially supported by the Russian Foundation for Basic Research (project no. 99-03-33111), by the Ministry of Science and Technology of the Russian Federation (project no 9.3.01), and by the Ministry of Education of the Russian Federation (project no. 015.05.01.13).

Selective mono-and diamination of polyfluorinated benzenes and pyridines with liquid ammonia

Amination of pentafluoropyridine, 2,3,5,6-tetrafluoropyridine, 4-chlorotetrafluoropyridine, 3,5-dichlorotrifluoropyridine, octafluorotoluene, α,α,α,2,3,5,6-heptafluorotoluene, decafluoro-m-xylene, decafluorobiphenyl, hexafluorobenzene, and pentafluorobenzene with liquid ammonia was investigated. Bis-aminodefluorination temperatures for the majority of substrates were shown to exceed significantly the corresponding temperatures of monoaminodefluorination. The optimal conditions for selective preparation of mono-and diaminopolyfluoro(het)arenes were elucidated. An efficient method for isolation of particular polyfluorophenylenediamines from product mixtures formed in nonselective reactions of pentafluorobenzene and hexafluorobenzene with aqueous ammonia based on complexation with a crown ether is proposed.