1198-97-6

Basic information

• Product Name: 4-Phenyl-2-pyrrolidinone
• Synonyms: 4-phenyl-2-pyrrolidinon;4-phenylpyrrolidone-2;4-PHENYL-2-PYRROLIDINONE;4-Phenyl-2-pyrrolidone;4-PHENYL-2-PYRIOLIDONE;4-phenylpyrrolidin-2-one;2-Pyrrolidinone,4-phenyl-;rac-4-Phenyl-pyrrolidin-2-one, 98%
• CAS NO: 1198-97-6
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2
• Mol File: 1198-97-6.mol
• Article Data: 23

Chemical Properties

• Melting Point: 72.0～78.0℃
• Boiling Point: 287.51°C (rough estimate)
• Flash Point: 212.4°C
• Appearance: /
• Density: 1.0840 (rough estimate)
• Vapor Pressure: 1.96E-05mmHg at 25°C
• Refractive Index: 1.5200 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 16.13±0.40(Predicted)
• CAS DataBase Reference: 4-Phenyl-2-pyrrolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Phenyl-2-pyrrolidinone(1198-97-6)
• EPA Substance Registry System: 4-Phenyl-2-pyrrolidinone(1198-97-6)

Safety Data

• Hazardous Substances Data: 1198-97-6(Hazardous Substances Data)

Usage

Uses

is used in the preparation of oxotremorine analogs as muscarinic antagonists. Also used in the synthesis of purrolidinylidemeureas as agents that act on the CNS.

InChI:InChI=1/C10H11NO/c12-10-6-9(7-11-10)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,11,12)

Synthetic route

2-oxo-4-phenylpyrrolidine-3-carboxylic acid (77519-55-2) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
In toluene for 5h; Reflux;	100%
at 190℃; for 0.5h;	58%
at 175℃;

4-nitro-3-phenylbutanoic acid methyl ester (34687-03-1) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 60℃; under 45004.5 Torr;	92%
With hydrogen; platinum(IV) oxide In methanol for 20h;	72%
With hydrogen; nickel In methanol at 60℃;

3-chloro-4-phenyl-1H-pyrrol-2(5H)-one → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
With sodium tetrahydroborate; nickel dichloride In tetrahydrofuran; methanol at 0 - 20℃; for 1h;	92%

ethyl 3-phenyl-4-nitrobutanoate (41441-40-1) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
With sodium tetrahydroborate; nickel(II) chloride hexahydrate In ethanol at 0℃; for 2h;	88%
With sodium tetrahydroborate; nickel(II) chloride hexahydrate In ethanol at 0℃; for 2h;	82%
With hydrogen; palladium on activated charcoal 1.) 2.) toluene, reflux; Yield given. Multistep reaction;
Stage #1: ethyl 3-phenyl-4-nitrobutanoate With hydrogen In ethanol at 20℃; under 1034.32 Torr; Stage #2: In ethanol; toluene Reflux;

C11H11N3O3 → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
Stage #1: C11H11N3O3 In chloroform at 60℃; for 3h; Inert atmosphere; Stage #2: With dmap In chloroform at 20℃; for 2h; Inert atmosphere;	87%

4-nitro-3-phenylbutanoic acid ethyl ester → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
With sodium tetrahydroborate; nickel(II) chloride hexahydrate; water In dichloromethane at -10 - 30℃; for 5h; Concentration; Reagent/catalyst; Temperature;	85%

4-amino-3-phenylbutanoic acid methyl ester (84872-79-7) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
With triethylamine In ethanol Reflux;	83%

(+/-)-4-nitro-3-phenylbutyric acid 4'-(4-nitro-3-phenylbutyryloxymethyl)-[2,2']bipyridinyl-4-ylmethyl ester (866789-27-7) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
With polymer-supported borohydride resin; nickel dichloride In dichloromethane at 20℃;	60%

4-(1,3-dioxoisoindolin-2-yl)-3-phenyl-N-(quinolin-8-yl)butanamide → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
With hydrazine hydrate In ethanol at 95℃; for 6h; Sealed tube;	59%

3-cyano-3-phenylpropanoic acid ethyl ester (14025-83-3) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
Stage #1: 3-cyano-3-phenylpropanoic acid ethyl ester With sodium tetrahydroborate; cobalt(II) chloride hexahydrate In tetrahydrofuran; water at 0 - 20℃; for 72h; Stage #2: With ammonia In tetrahydrofuran; water	57%
Multi-step reaction with 2 steps 1: H2, conc. HCl / 10percent Pd/C / methanol / 2068.6 Torr 2: Et3N / toluene / Heating View Scheme

2-pyrrolidinon (616-45-5) + bromobenzene (108-86-1) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
With aluminum (III) chloride; sodium chloride at 0 - 180℃; under 750.075 Torr;	44%

4-nitro-3-phenylbutanoic acid polyglyceryl ester → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
With hydrogenchloride; zinc In ethanol Heating;	36%

(2-nitro-1-phenyl-ethyl)-malonic acid dimethyl ester (55790-16-4) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
With palladium on activated carbon; hydrogen In o-xylene at 130℃; under 11251.1 Torr; for 18h; Catalytic behavior;	35%
Multi-step reaction with 3 steps 1: hydrogen / methanol / 2.5 h / 20 °C / 3102.97 Torr 2: sodium hydroxide / ethanol / 48 h / 20 °C 3: toluene / 5 h / Reflux View Scheme

2-pyrrolidinon (616-45-5) + chlorobenzene (108-90-7) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
With aluminum (III) chloride; sodium chloride at 0 - 180℃; under 750.075 Torr;	32%

2-oxo-4-phenyl-3-ethoxycarbonylpyrrolidine (52450-32-5) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
With hydrogenchloride; ethanol; water
Multi-step reaction with 2 steps 1: ethanolic KOH 2: 175 °C View Scheme
With sodium carbonate for 6h; Reagent/catalyst; Reflux;	3.3 g

4-amino-3-phenylbutanoic acid (1078-21-3) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
With potassium hydroxide

ethyl 4-amino-3-phenylbutanoate hydrochloride → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
With triethylamine In toluene Heating;

(+-)-3-cyano-3-phenyl-propionic acid ethyl ester → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
With diethyl ether; nickel at 70 - 90℃; Hydrogenation;

Methyl cinnamate (103-26-4) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: 96 percent / 1,1,3,3-tetramethylguanidine / 3 h / Heating 2: 72 percent / H2 / PtO2 / methanol / 20 h View Scheme
Multi-step reaction with 2 steps 1: 1,1,3,3-tetramethylguanidine / 70 °C 2: H2 / Raney nickel / methanol / 60 °C View Scheme
Multi-step reaction with 2 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol 2: hydrogen / platinum(IV) oxide / ethanol View Scheme
Multi-step reaction with 3 steps 1: N,N,N',N'-tetramethylguanidine / 42 h / 20 °C 2: palladium 10% on activated carbon; acetic acid; hydrogen / dichloromethane / 20 °C 3: triethylamine / ethanol / Reflux View Scheme

diethyl benzalmalonate (5292-53-5) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
Multi-step reaction with 3 steps 1: methanol; H2O / 60 °C 2: H2, conc. HCl / 10percent Pd/C / methanol / 2068.6 Torr 3: Et3N / toluene / Heating View Scheme

3-methoxycarbonyl-4-phenyl-2-pyrrolidone (55790-17-5) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: 89.6 percent / 10percent aq. KOH / 5 h / Heating 2: 58 percent / 0.5 h / 190 °C View Scheme
Multi-step reaction with 2 steps 1: sodium hydroxide / ethanol / 48 h / 20 °C 2: toluene / 5 h / Reflux View Scheme

3-chloro-5-hydroxy-4-phenylfuran-2(5H)-one → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: acetic acid / chloroform / 1 h / 0 - 20 °C 1.2: 20 °C 2.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 80 °C 3.1: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / 0 - 20 °C View Scheme

3-chloro-1-(2,4-dimethoxybenzyl)-4-phenyl-1H-pyrrol-2(5H)-one → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 80 °C 2: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / 0 - 20 °C View Scheme

phenylboronic acid (98-80-6) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions

Yield

Multi-step reaction with 4 steps 1.1: cesium fluoride; tetrabutyl-ammonium chloride; bis-triphenylphosphine-palladium(II) chloride / toluene; water / 18 h / 20 °C / Inert atmosphere 2.1: acetic acid / chloroform / 1 h / 0 - 20 °C 2.2: 20 °C 3.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 80 °C 4.1: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / 0 - 20 °C View Scheme

ethyl 3-phenyl-2-propenoate (103-36-6) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C 2.1: hydrogen / ethanol / 20 °C / 1034.32 Torr 2.2: Reflux View Scheme
Multi-step reaction with 2 steps 1: sodium hydroxide / methanol; water / 24 h / 20 - 30 °C 2: nickel(II) chloride hexahydrate; water; sodium tetrahydroborate / dichloromethane / 5 h / -10 - 30 °C View Scheme

benzaldehyde (100-52-7) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: tetrahydrofuran / 20 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C 3.1: hydrogen / ethanol / 20 °C / 1034.32 Torr 3.2: Reflux View Scheme
Multi-step reaction with 2 steps 1: aminopropyl-silica-based catalyst; dimethylaminopropyl-silica-based solid / o-xylene / 18 h / 70 °C / Green chemistry 2: palladium on activated carbon; hydrogen / o-xylene / 18 h / 130 °C / 11251.1 Torr View Scheme
Multi-step reaction with 3 steps 1.1: potassium tert-butylate / toluene; methanol / 0.17 h / 20 °C / 4500.45 Torr / Inert atmosphere 1.2: 0.11 h / 25 °C / 4500.45 Torr / Inert atmosphere 2.1: tetrabutyl ammonium fluoride / toluene; tetrahydrofuran / 1 h / 50 °C / 6000.6 Torr 3.1: hydrogen; palladium 10% on activated carbon / methanol / 60 °C / 45004.5 Torr View Scheme

(2-nitroethenyl)benzene (102-96-5) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: calcined hydrotalcite / ethanol / 24 h / Reflux 2: nickel(II) chloride hexahydrate; sodium tetrahydroborate / ethanol / 2 h / 0 °C View Scheme
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 24 h / 25 °C 2: calcined hydrotalcite / 24 h / Reflux 3: nickel(II) chloride hexahydrate; sodium tetrahydroborate / ethanol / 2 h / 0 °C View Scheme

benzyl alcohol (100-51-6) → 4-phenylpyrrolidin-2-one (1198-97-6)

Conditions

Yield

Multi-step reaction with 4 steps 1.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium hypochlorite; potassium bromide / water; dichloromethane / 0.21 h / 0 °C 2.1: potassium tert-butylate / toluene; methanol / 0.17 h / 20 °C / 4500.45 Torr / Inert atmosphere 2.2: 0.11 h / 25 °C / 4500.45 Torr / Inert atmosphere 3.1: tetrabutyl ammonium fluoride / toluene; tetrahydrofuran / 1 h / 50 °C / 6000.6 Torr 4.1: hydrogen; palladium 10% on activated carbon / methanol / 60 °C / 45004.5 Torr View Scheme

4-phenylpyrrolidin-2-one (1198-97-6) + propargyl bromide (106-96-7) → N-propargyl-4-phenyl-2-pyrrolidone (137518-26-4)

Conditions	Yield
With potassium hydroxide; tetrabutylammomium bromide In tetrahydrofuran at 0 - 20℃; for 6h;	97%

4-phenylpyrrolidin-2-one (1198-97-6) + (R)-1-(1-naphthyl)ethyl isocyanate (42340-98-7) → N-<(R)-1-(1-naphthyl)ethyl>-4-phenyl-2-pyrrolidone-1-carboxamide (916345-91-0)

Conditions	Yield
In benzene for 24h; Heating;	95%

4-phenylpyrrolidin-2-one (1198-97-6) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → 4-phenyl-1-(trimethylsilyl)-2-pyrrolidinone (106869-48-1)

Conditions	Yield
With hydrogenchloride for 0.333333h; Heating;	90%

4-phenylpyrrolidin-2-one (1198-97-6)

Conditions	Yield
With hydrogenchloride; water for 12h; Reflux;	88%
With hydrogenchloride In water for 12h; Reflux;	88%
With hydrogenchloride In water for 16h; Sealed tube; Reflux;	65%
With hydrogenchloride; water In water for 16h; Reflux;	55%

4-phenylpyrrolidin-2-one (1198-97-6) + methyl iodide (74-88-4) → 1-methyl-4-phenyl-pyrrolidin-2-one (54520-84-2)

Conditions	Yield
Stage #1: 4-phenylpyrrolidin-2-one With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Sealed tube; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 20℃; Sealed tube; Inert atmosphere;	88%

4-phenylpyrrolidin-2-one (1198-97-6) + methyl chloroacetate (96-34-4) → methyl-2-oxo-4-phenylpyrrolidine-1-acetate (68497-63-2)

Conditions	Yield
Stage #1: 4-phenylpyrrolidin-2-one With potassium tert-butylate In N,N-dimethyl-formamide at -10℃; for 2h; Stage #2: methyl chloroacetate In N,N-dimethyl-formamide at -10 - 0℃; for 2h; Concentration; Temperature; Solvent;	84%
With sodium methylate 1.) toluene, 150-160 deg C, 2.) toluene, 60-70 deg C, 2 h; Yield given. Multistep reaction;
In tetrahydrofuran; water; mineral oil

4-phenylpyrrolidin-2-one (1198-97-6) + 3-bromo-5-[methyl(methylsulfonyl)amino]benzoic acid methyl ester (924650-17-9) → 3-[methyl(methylsulfonyl)amino]-5-(2-oxo-4-phenylpyrrolidine-1-yl)benzoic acid methyl ester (929041-94-1)

Conditions	Yield
With caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 7h;	82%

4-phenylpyrrolidin-2-one (1198-97-6) + triethyloxonium fluoroborate (368-39-8) → Ethoxy-2 phenyl-4 Δ1-pyrroline (22349-33-3)

Conditions	Yield
	81%

4-phenylpyrrolidin-2-one (1198-97-6) + 4-chlorophenyloxyacetyl chloride (4122-68-3) → N-(4-chlorophenoxyacetyl)-4-phenyl-pyrrolidin-2-one

Conditions	Yield
With triethylamine In toluene	76.5%

formaldehyd (50-00-0) + 4-phenylpyrrolidin-2-one (1198-97-6) → 1-chloromethyl-4-phenylpyrrolidin-2-one (68116-87-0)

Conditions	Yield
With chloro-trimethyl-silane for 1h; Heating;	67.5%

nicotinic acid (59-67-6) + 4-phenylpyrrolidin-2-one (1198-97-6) → N-nicotinoyl-4-phenyl-pyrrolidin-2-one + N-(4-chlorobenzoyl)-4-phenyl-pyrrolidin-2-one

Conditions	Yield
With thionyl chloride; triethylamine In toluene	A 58.5% B 65.4%

4-phenylpyrrolidin-2-one (1198-97-6) + iodobenzene (591-50-4) → 1,4-diphenylpyrrolidin-2-one (2889-64-7)

Conditions	Yield
With copper(l) iodide; potassium carbonate; 1,3-bis(methylamino)propane In 1,4-dioxane for 24h; Reflux;	60%

4-phenylpyrrolidin-2-one (1198-97-6) + 4-iodo-N-(quinolin-8-yl)benzamide (1203050-38-7) → C26H21N3O2 (1437789-57-5)

Conditions	Yield
With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine In 1,4-dioxane at 140℃; Microwave irradiation;	59%

4-phenylpyrrolidin-2-one (1198-97-6) → 1-ethyl-4-phenyl-pyrrolidin-2-one

Conditions	Yield
In tetrahydrofuran	57%

4-phenylpyrrolidin-2-one (1198-97-6) + 2-(3-cyano-4-fluorophenoxy)ethyl methanesulfonate → 2-fluoro-5-[2-(2-oxo-4-phenylpyrrolidin-1-yl)ethoxy]benzonitrile

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 80℃; for 1h; Inert atmosphere;	55%

4-phenylpyrrolidin-2-one (1198-97-6) + benzyl bromide (100-39-0) → 1-benzyl-4-phenylpyrrolidin-2-one (108303-98-6)

Conditions	Yield
With 18-crown-6 ether; sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.5h;	52%
With sodium hydride 1.) xylene, reflux, 5 h, 2.) xylene, reflux, 4 h; Yield given. Multistep reaction;

4-phenylpyrrolidin-2-one (1198-97-6) + 1-(2,2,2-trifluoroacetyl)indolin-5-ylsulfonyl chloride (210691-38-6) → 4-phenyl-1-(1-(2,2,2-trifluoroacetyl)indolin-5-ylsulfonyl)pyrrolidin-2-one

Conditions	Yield
Stage #1: 4-phenylpyrrolidin-2-one With n-butyllithium In tetrahydrofuran for 0.5h; Stage #2: 1-(2,2,2-trifluoroacetyl)indolin-5-ylsulfonyl chloride In tetrahydrofuran at 0℃; for 4h;	45%

4-phenylpyrrolidin-2-one (1198-97-6) → 4-phenyl-2-pyrrolidinethione (22349-31-1)

Conditions	Yield
With diphosphorus pentasulfide In o-xylene Heating;	40%

4-phenylpyrrolidin-2-one (1198-97-6) + oxalic acid (144-62-7) + 2-(diethylamino)ethyl chloride (100-35-6) → 1-(2-diethylaminoethyl)-4-phenyl-2-pyrrolidinone oxalate

Conditions	Yield
Stage #1: 4-phenylpyrrolidin-2-one With sodium hydride In N,N-dimethyl-formamide at 20 - 50℃; for 1h; Metallation; Stage #2: 2-(diethylamino)ethyl chloride In N,N-dimethyl-formamide at 80℃; for 8h; Alkylation; Stage #3: oxalic acid In diethyl ether; ethanol acid-base reaction;	37.5%

Upstream product

• 864294-75-7 2,2-dimethyl-5-(2-nitro-1-phenyleth-1-yl)-1,3-dioxane-4,6-dione 
• 1214-54-6 5-benzylidene Meldrum's acid 
• 141377-54-0 2-nitro-1-phenylethan-1-ol 
• 71639-13-9 diethyl 2-(3-nitrophenylethyl)malonate 
• 614-21-1 2-nitroacetophenone 
• 616-45-5 2-pyrrolidinon 
• 108-86-1 bromobenzene 
• 108-90-7 chlorobenzene 
• 4160-80-9 3-phenylglutaric acid anhydride 
• 84872-79-7 4-amino-3-phenylbutanoic acid methyl ester 
• 6626-84-2 dimethyl 2-benzylidenepropanedioate 
• 102-96-5 (2-nitroethenyl)benzene 
• 55790-16-4 (2-nitro-1-phenyl-ethyl)-malonic acid dimethyl ester 
• 98-80-6 phenylboronic acid 

Downstream Products

• 22349-31-1 4-phenyl-2-pyrrolidinethione 
• 70291-40-6 2-oxo-4-phenyl-1-pyrrolidineacetic acid, ethyl ester 
• 22349-30-0 2-imino-4-phenylpyrrolidine 
• 208844-53-5 (2-oxo-4-phenyl-1-pyrrolidinyl)acetic acid carboethoxymethyl ester 
• 3060-41-1 (±)-3-carboxy-2-phenylpropan-1-aminium chloride 
• 68116-73-4 1-hydroxymethyl-4-phenyl-pyrrolidin-2-one 
• 71657-88-0 (4R)-4-phenyl-2-pyrrolidone 
• 54520-84-2 1-methyl-4-phenyl-pyrrolidin-2-one 
• 62624-45-7 (S)-4-phenyl-1-tosylpyrrolidin-2-one 
• 108303-98-6 N-benzyl-4-phenylpyrrolidin-2-one 
• 106869-48-1 4-phenyl-1-(trimethylsilyl)-2-pyrrolidinone 

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The invention discloses a synthesis method of 4-phenyl-2-pyrrolidone, which comprises the following steps: by using diethyl malonate and 2-nitro-1-phenethyl ketone as raw materials, carrying out condensation reaction by using a strong Lewis base to obtain an intermediate 1, and reacting the intermediate 1 in an organic solvent under the action of palladium-carbon catalytic hydrogenation to obtain an intermediate 3-(3-methoxy carboxyl -4-phenyl-2-pyrrolidone); and finally, carrying out decarboxylation reaction under the alkaline condition of an organic solvent to obtain the final 4-phenyl-2-pyrrolidone. In addition, 4-phenyl-2-pyrrolidone can also be prepared through a Fork alkylation reaction of pyrrolidone and halogenated benzene by a one-step method. The method disclosed by the invention has the characteristics of readily available raw materials, simple reaction conditions, high yield and the like.