1198-99-8

Basic information

• Product Name: 3-pyridin-3-yl-2H-1,2,4-oxadiazol-5-one
• Synonyms: 3-pyridin-3-yl-2H-1,2,4-oxadiazol-5-one;3-Pyridin-3-yl-4H-[1,2,4]oxadiazol-5-one;3-Pyridin-3-yl-[1,2,4]oxadiazol-5-ol;3-(Pyridin-3-yl)-1,2,4-oxadiazol-5(4H)-one;3-(Pyridin-3-Yl)-4,5-Dihydro-1,2,4-Oxadiazol-5-One(WXC03594)
• CAS NO: 1198-99-8
• Molecular Formula: C7H5N3O2
• Molecular Weight: 163.13
• Mol File: 1198-99-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 267.9°Cat760mmHg
• Flash Point: 115.8°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 0.00793mmHg at 25°C
• Refractive Index: 1.702
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-pyridin-3-yl-2H-1,2,4-oxadiazol-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-pyridin-3-yl-2H-1,2,4-oxadiazol-5-one(1198-99-8)
• EPA Substance Registry System: 3-pyridin-3-yl-2H-1,2,4-oxadiazol-5-one(1198-99-8)

Safety Data

• Hazardous Substances Data: 1198-99-8(Hazardous Substances Data)

Usage

General Description

3-pyridin-3-yl-2H-1,2,4-oxadiazol-5-one is a heterocyclic compound containing a pyridine ring and an oxadiazole ring. It is commonly used in organic synthesis and medicinal chemistry as a building block for the production of various pharmaceuticals and agrochemicals. The compound exhibits promising biological activities, including antimicrobial, antifungal, and anti-inflammatory properties, making it a valuable molecule for drug discovery and development. Its unique structural features and versatile reactivity also make it a valuable tool for the construction of diverse chemical libraries and the generation of novel drug candidates.

InChI:InChI=1/C7H5N3O2/c11-7-9-6(10-12-7)5-2-1-3-8-4-5/h1-4H,(H,9,10,11)

Upstream product

• 1594-58-7 nicotinamide oxime 
• 541-41-3 chloroformic acid ethyl ester 
• 463-72-9 carbamic chloride 
• 100-54-9 pyridine-3-carbonitrile 

Relevant articles and documents

Synthesis and antibacterial activity of novel pyridine and pyrazine derivatives obtained from amidoximes

(Chemical Equation Presented) The new pyridine, 4-pyridine N-oxide and pyrazine derivatives exhibiting an antibacterial activity have been synthesized. Amidoximes were transformed into N-hydroxyimidoyl chlorides and then into appropriate oximes. Upon treatment of pyridinecaboxamidoximes with methyl iodide 1-methylpyridynium iodides were formed. Reaction of amidoximes with various carbamoyl chlorides led to corresponding 5-aminocarbonyl-1,2,4-oxadiazoles. Some of carboxamides have undergone thermal decarboxylation to tertiary amines. The newly synthesized compounds were tested in vitro for their tuberculostatic activity. MIC of the most active compound 9 was 12.5 μg/mL for H 37Rv strain. Their activity towards 25 strains of anaerobic and 25 strains of aerobic bacteria was also studied. Derivative 18 was active against both aerobic and anaerobic types of the bacteria.