119808-36-5Relevant articles and documents
Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors
Suzuki, Nobuaki,Suzuki, Takayoshi,Ota, Yosuke,Nakano, Tatsuya,Kurihara, Masaaki,Okuda, Haruhiro,Yamori, Takao,Tsumoto, Hiroki,Nakagawa, Hidehiko,Miyata, Naoki
experimental part, p. 2909 - 2922 (2010/01/16)
Guided by the proposed catalytic mechanism of histone deacetylases (HDACs), we designed and synthesized a series of boronic acid-based HDAC inhibitors bearing an R-amino acid moiety. In this series, compounds (S)-18, 20, and 21 showed potent HDAC-inhibito