1198080-53-3 Usage
Uses
Used in Pharmaceutical Industry:
1-(2R)-1-[(11bR)-Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yloxy]propan-2-yl-3-phenylurea, min. 97% UREAPhos is used as a ligand in the synthesis of pharmaceuticals. Its high efficiency and selectivity in metal-catalyzed organic transformations enable the production of enantiomerically pure compounds, which are essential for the development of chiral drugs with improved efficacy and reduced side effects.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(2R)-1-[(11bR)-Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yloxy]propan-2-yl-3-phenylurea, min. 97% UREAPhos is utilized as a ligand for the synthesis of chiral agrochemicals. Its ability to facilitate enantioselective reactions contributes to the development of more effective and environmentally friendly pesticides and herbicides.
Used in Academic Research:
1-(2R)-1-[(11bR)-Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yloxy]propan-2-yl-3-phenylurea, min. 97% UREAPhos is employed as a ligand in academic research laboratories for the study of metal-catalyzed organic transformations. Its high efficiency and selectivity make it a valuable tool for exploring new reaction pathways and developing innovative synthetic methods.
Used in Industrial Research Laboratories:
In industrial research laboratories, 1-(2R)-1-[(11bR)-Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yloxy]propan-2-yl-3-phenylurea, min. 97% UREAPhos is used as a ligand for the development of new catalytic processes and the optimization of existing ones. Its performance in asymmetric hydrogenation and other metal-catalyzed reactions helps improve the efficiency and selectivity of industrial chemical syntheses, leading to more sustainable and cost-effective production methods.
Overall, 1-(2R)-1-[(11bR)-Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yloxy]propan-2-yl-3-phenylurea, min. 97% UREAPhos is a versatile and valuable compound in the fields of pharmaceuticals, agrochemicals, and chemical research, owing to its exceptional performance as a ligand in metal-catalyzed organic transformations.
Check Digit Verification of cas no
The CAS Registry Mumber 1198080-53-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,8,0,8 and 0 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1198080-53:
(9*1)+(8*1)+(7*9)+(6*8)+(5*0)+(4*8)+(3*0)+(2*5)+(1*3)=173
173 % 10 = 3
So 1198080-53-3 is a valid CAS Registry Number.
1198080-53-3Relevant academic research and scientific papers
Sandee, Albertus J.,Van Der Burg, Alida M.,Reek, Joost N. H.
, p. 864 - 866 (2007)
Supramolecular bidentate phosphite ligands are presented as a new class of ligands for rhodium catalysed asymmetric hydrogenation. The Royal Society of Chemistry.
Application of a Supramolecular-Ligand Library for the Automated Search for Catalysts for the Asymmetric Hydrogenation of Industrially Relevant Substrates
Meeuwissen, Jurjen,Kuil, Mark,Van Der Burg, Alida M.,Sandee, Albertus J.,Reek, Joost N. H.
experimental part, p. 10272 - 10279 (2010/04/05)
A procedure is described for the automated screening and lead optimization of a supramolecular-ligand library for the rhodium-catalyzed asymmetric hydrogenation of five challenging substrates relevant to industry. Each catalyst is (self-) assembled from two urea-functionalized ligands and a transition-metal center through hydrogen-bonding interactions. The modular ligand structure consists of three distinctive fragments: the urea binding motif, the spacer, and the ligand backbone, which carries the phosphorus donor atom. The building blocks for the ligand synthesis are widely available on a commercial basis, thus ena-bling access to a large number of ligands of high structural diversity. The simple synthetic steps enabled the scale-up of the ligand synthesis to multigram quantities. For the catalyst screening, a library of twelve new chiral ligands was prepared that comprised substantial variation in electronic and steric properties. The automated procedures employed ensured the fast catalyst assembly, screening, and direct acquisition of samples for analysis. It appeared that the most selective catalyst was different for every substrate investigated and that small variations in the building blocks had a major impact on the catalyst performance. For two substrates, a catalyst was found that provided the product with outstanding enantioselectivity. The subsequent automated optimization of these two leads showed that an increase of catalyst loading, dihydrogen pressure, and temperature had a positive effect on the catalyst activity without affecting the catalyst selectivity.
