1198107-13-9

Basic information

• Product Name: (R)-N-(1-(2-chlorophenyl)ethyl)benzamide
• Synonyms: (R)-N-(1-(2-chlorophenyl)ethyl)benzamide
• CAS NO: 1198107-13-9
• Molecular Weight: 259.735
• Mol File: 1198107-13-9.mol

Chemical Properties

• CAS DataBase Reference: (R)-N-(1-(2-chlorophenyl)ethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(1-(2-chlorophenyl)ethyl)benzamide(1198107-13-9)
• EPA Substance Registry System: (R)-N-(1-(2-chlorophenyl)ethyl)benzamide(1198107-13-9)

Safety Data

• Hazardous Substances Data: 1198107-13-9(Hazardous Substances Data)

Upstream product

• 39959-67-6 1-(2-Chloro-phenyl)-ethylamine 
• 93-97-0 benzoic acid anhydride 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 1149756-73-9 2-methylpropane-2-sulfinic acid [1-(2-chlorophenyl)ethylidene]amide 

Relevant articles and documents

Kinetic resolution of amines via dual catalysis: Remarkable dependence of selectivity on the achiral cocatalyst

A dual-catalysis/anion-binding approach with a chiral hydrogen bonding (HB) catalyst and an achiral nucleophilic cocatalyst was applied to the kinetic resolution of amines. Out of a structurally diverse collection of 22 nucleophilic species, 4-di-n-propylaminopyridine emerged as the most efficient cocatalyst, allowing for the kinetic resolution of benzylic amines with s-factors of up to 67.

A versatile Ru catalyst for the asymmetric transfer hydrogenation of both aromatic and aliphatic sulfinylimines

A highly efficient Ru catalyst based on an achiral, very simple, and inexpensive amino alcohol ligand (2-amino-2-methylpropan-1-ol) has been developed for the asymmetric transfer hydrogenation (ATH) of chiral N-(tert-butylsulfinyl)imines. This complex is able to catalyze the ATH of both aromatic and the most challenging aliphatic sulfinylimines by using isopropyl alcohol as the hydrogen source. The diastereoselective reduction of aromatic, heteroaromatic, and aliphatic sulfinylketimines, including sterically congested cases, over short reaction times (1-4 h), followed by desulfinylation of the nitrogen atom, affords the corresponding highly enantiomerically enriched (ee up to >99%) α-branched primary amines in excellent yields. The same ligand was equally effective for the synthesis of both (R)- and (S)-amines by using the appropriate absolute configuration in the iminic substrate. DFT mechanistic studies show that the hydrogen-transfer process is stepwise. Moreover, the origin of the diastereoselectivity has been rationalized.