1198107-13-9Relevant articles and documents
Kinetic resolution of amines via dual catalysis: Remarkable dependence of selectivity on the achiral cocatalyst
Mittal, Nisha,Sun, Diana X.,Seidel, Daniel
, p. 3084 - 3087 (2012)
A dual-catalysis/anion-binding approach with a chiral hydrogen bonding (HB) catalyst and an achiral nucleophilic cocatalyst was applied to the kinetic resolution of amines. Out of a structurally diverse collection of 22 nucleophilic species, 4-di-n-propylaminopyridine emerged as the most efficient cocatalyst, allowing for the kinetic resolution of benzylic amines with s-factors of up to 67.