119817-95-7Relevant articles and documents
Lipase catalysed synthesis of optically enriched α-haloamides
Azim, Abul,Sharma, Sunil K.,Olsen, Carl E.,Parmar, Virinder S.
, p. 1345 - 1348 (2001)
An efficient lipase catalysed synthesis of optically enriched α-halogenated amides with concomitant optical enrichment of the starting α-haloesters is described. Candida antarctica lipase (CAL) was found to be a better catalyst over porcine pancreatic lipase (PPL) and Candida cylindracea lipase (CCL). The effect of different organic solvents was also studied.
Enantioselective aminolysis of an alpha-chloroester catalyzed by Candida cylindracea lipase encapsulated in sol-gel silica glass.
Badjic,Kadnikova,Kostic
, p. 2025 - 2028 (2001)
[reaction: see text] Lipase from Candida cylindracea (CcL) encapsulated in porous silica glass by a sol-gel method catalyzes enantioselective aminolysis of ethyl 2-chloropropionate. A silica matrix enhances the enzyme activity, i.e., improves the yield. T
DOTMA-based amides (DOTMAMs) as a platform for the development of PARACEST MRI contrast agents
Suchy,Li,Milne,Bartha,Hudson
, p. 62647 - 62655 (2016/07/16)
A synthetic methodology leading to previously unknown DOTMA-based secondary amides (DOTMAMs) has been developed. Alkylation of cyclen with l-lactic acid-derived pseudohalides was used as a key step affording the alkyl- and aryl-decorated DOTMAMs. Amino acid-decorated DOTMAMs were obtained via peptide coupling between DOTMA and protected amino acids. Metallation of the DOTMAMs ligand with Tm3+ gave complexes exhibiting proximal amide proton based paramagnetic CEST effects at -50 ppm relative to water.
Microwave synthesis of chiral N-benzyl-2-methyl-2H-benzo[b][1, 4]oxazin/thiazin-3(4H)-ones via smiles rearrangement and their biological evaluation
Meng, Li-Juan,Zuo, Hua,Vijaykumar,Dupati, Gautam,Choi, Kyung-Min,Jang, Kiwan,Yoon, Yong-Jin,Shin, Dong-Soo
, p. 585 - 589 (2013/08/25)
Optically active N-benzyl-2-methyl-2H-benzo[b][1,4]oxazin-3(4H)-ones and N-benzyl-2-methyl-2H-benzo [b][1, 4]thiazin-3(4H)-ones with potential synthetic and pharmacological interest were prepared via Smiles rearrangement in conventional as well as microwa
Enzymatic Aminolysis and Transamidation Reactions
Gotor, Vicente,Brieva, Rosario,Gonzalez, Carmen,Rebolledo, Francisca
, p. 9207 - 9214 (2007/10/02)
Chiral amides can be obtained from (+/-)-2-chloropropionate esters and a wide range of amines when the reaction is catalyzed by Candida cylindracea lipase.The enantioselection of the enzyme in this aminolysis reaction depends on the substrate and nucleoph
CONTROL OF ENANTIOSELECTIVITY IN THE FORMATION OF A MODEL ALANINAMIDE FROM A 2-BROMOPROPANAMIDE
D'Angeli, Ferruccio,Marchetti, Paolo,Cavicchioni, Giorgio,Catelani, Giorgio,Nejad, F. Moftakhari Kamrani
, p. 155 - 158 (2007/10/02)
Reactions of (R)- or (S)-2-chloro or -bromopropanamides 1,2 and related compounds with benzylamine in the presence of AlCl3, Ag2O, or a lipase (CCL) in an organic solvent, are described.N,N'-Dibenzylalaninamide 6 of either optical activity is obtained from optically active 2 by proper use of Ag2O.
A SIMPLE PROCEDURE FOR THE PREPARATION OF CHIRAL AMIDES
Gotor, Vicente,Brieva, Rosario,Rebolledo, Francisca
, p. 6973 - 6974 (2007/10/02)
Yeast lipase (Candida cylindracea) catalysed the reaction between ethyl (+/-)-2-chloropropionate and different aliphatic and aromatic amines yielding optically active amides.