119820-58-5Relevant academic research and scientific papers
Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds
Patil,Jones,Nair,Galivan,Maley,Kisliuk,Gaumont,Duch,Ferone
, p. 1284 - 1289 (2007/10/02)
The chemical synthesis of three close analogues (2-4) of N10-propargyl-5,8-dideazafolate (PDDF) is described. The quinazoline ring of 2 and 4 was constructed from the pivotal intermediate 9 in a novel and unambiguous manner during the final ste
