1198214-09-3Relevant articles and documents
Ruthenium-catalyzed direct C3 alkylation of indoles with α,β-unsaturated ketones
Li, Shuai-Shuai,Lin, Hui,Zhang, Xiao-Mei,Dong, Lin
, p. 1254 - 1263 (2015)
In this paper, a simple and highly efficient ruthenium-catalyzed direct C3 alkylation of indoles with various α,β-unsaturated ketones without chelation assistance has been developed. This novel C-H activation methodology exhibits a broad substrate scope s
Indirect regioselective heteroarylation of indoles through a Friedel-Crafts reaction with (E)-1,4-diaryl-2-buten-1,4-diones
Blay, Gonzalo,Fernández, Isabel,Monleón, Alicia,Pedro, José R.,Vila, Carlos
experimental part, p. 9264 - 9270 (2010/01/06)
A two-step synthesis of 3-heteroaryl indoles has been developed. The first step of the sequence involves a Friedel-Crafts alkylation of indoles with 1,4-diaryl-2-buten-1,4-diones to give the corresponding indoles bearing a 1,4-dicarbonyl moiety. The reaction is catalyzed by InCl3 and takes place with good yields. Cyclization of the diones under different Paal-Knorr conditions allows to prepare indoles substituted at the C3 position with 3-furanyl, 3-pyrrolyl- and 3-thienyl moieties.