1198272-70-6

Basic information

• Product Name: 4-methyl-N-(prop-2-yn-1-yl)-N-(p-tolyl)benzenesulfonamide
• Synonyms: 4-methyl-N-(prop-2-yn-1-yl)-N-(p-tolyl)benzenesulfonamide
• CAS NO: 1198272-70-6
• Molecular Weight: 299.393
• Mol File: 1198272-70-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4-methyl-N-(prop-2-yn-1-yl)-N-(p-tolyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-(prop-2-yn-1-yl)-N-(p-tolyl)benzenesulfonamide(1198272-70-6)
• EPA Substance Registry System: 4-methyl-N-(prop-2-yn-1-yl)-N-(p-tolyl)benzenesulfonamide(1198272-70-6)

Safety Data

• Hazardous Substances Data: 1198272-70-6(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 98-59-9 p-toluenesulfonyl chloride 
• 599-86-0 4-methyl-N-(4-methylphenyl)benzenesulfonamide 
• 106-96-7 propargyl bromide 

Downstream Products

• 76061-97-7 4-Phenyl-6-methylquinoline 
• 1220993-62-3 4-methyl-N-(3-phenylprop-2-yn-1-yl)-N-(p-tolyl)benzenesulfonamide 
• 1395894-75-3 C₂₄H₂₃NO₃S 
• 1395894-76-4 C₂₅H₂₃NO₄S 

Relevant articles and documents

Dynamic Kinetic Resolution in Gold-Catalyzed (4 + 2)-Annulations between Alkynyl Benzaldehydes and Allenamides to Yield Enantioenriched All-Carbon Diarylalkylmethane Derivatives

This work reports the synthesis of diarylmethane derivatives via gold-catalyzed (4 + 2)-annulations between alkynyl benzaldehydes and allenamides, followed by an aza-Claisen rearrangement. Deuterium labeling and crossover experiments have been performed to confirm this proposed mechanism. With racemic 3-substituted allenamides in a substrate ratio (1:1), we employ chiral gold catalysts to achieve a dynamic kinetic resolution to obtain enantioenriched diarylalkylmethane derivatives with high e.r. levels (up to 93:7).

Iron-Mediated Cyclization of 1,3-Diynyl Propargyl Aryl Ethers with Dibutyl Diselenide: Synthesis of Selenophene-Fused Chromenes

The synthesis of selenophene-fused chromene derivatives starting from 1,3-diynyl propargyl aryl ethers is reported herein. The method is based on carbon-carbon, carbon-selenium, selenium-carbon and carbon-selenium bonds formation in a one-pot protocol, using iron(III) chloride and dibutyl diselenide as promoters. The same reaction conditions were applied to propargyl anilines leading to the formation of 1-(butylselanyl)-selenophene quinolines. The results showed that the dilution and temperature of substrate addition had a crucial influence in the products obtained. When the substrates were added at room temperature, in the absence of a solvent, a mixture of products was obtained, whereas the slowly addition (15 min) of starting materials, as a dichloromethane solution, at 0 °C led to the product formation in good yields. The mechanistic study indicates that the cooperative action between iron(III) chloride and dibutyl diselenide was essential to promote the cyclization, whereas separately none of them was effective in promoting the cyclization. We proved the synthetic utility of heterocycles obtained in the Suzuki cross coupling reaction, giving the corresponding cross-coupled products in good yields. In addition, the organoselenium moiety was removed from the structures of products by using n-butyllithium. (Figure presented.).

Intramolecular annulation of aromatic rings with N-sulfonyl 1,2,3-triazoles: Divergent synthesis of 3-methylene-2,3-dihydrobenzofurans and 3-methylene-2,3-dihydroindoles

The controllable synthesis of 3-methylene-2,3-dihydrobenzofurans 2 and 3-methylene-2,3-dihydroindoles 5 has been developed through Rh-catalyzed intramolecular annulation of aromatic rings with azavinyl carbenes. This journal is