1198273-21-0Relevant articles and documents
Consecutive C-H functionalization reactions of arenes: Synthesis of carbo- and heteropolycyclic skeletons
Suarez-Pantiga, Samuel,Palomas, David,Rubio, Eduardo,Gonzalez, Jose M.
, p. 7857 - 7861 (2009)
Doubling the bet: Two C-H bonds become functionalized upon exposure of co-aryl propargylic tosylates to Sc(OTf)3 (see scheme). The reaction involves a new domino process that can tolerate both electron-withdrawing and -donating substituents on the arene unit. Different carbo- and heterocyclic frameworks can be assembled by using this approach to formally conquer the hydroarylation process.