1198278-76-0Relevant articles and documents
An expedient synthesis of poly-substituted 1-arylisoquinolines from δ-ketonitriles via indium-mediated Barbier reaction protocol
Kim, Sung Hwan,Lee, Hyun Seung,Kim, Ko Hoon,Kim, Jae Nyoung
experimental part, p. 6476 - 6479 (2011/02/23)
We developed an efficient synthetic strategy of poly-substituted 1-arylisoquinolines via an indium-mediated Barbier type allylation from δ-ketonitriles. Initial attack of allylindium species occurred at the nitrile group selectively to form the enamine intermediate, which reacted with the ketone group intramolecularly to furnish the isoquinolines.