1198320-01-2Relevant academic research and scientific papers
Facile and practical synthesis of a cannabinoid-1 antagonist via regio- and stereoselective ring-opening of an aziridinium ion
Villhauer, Edwin B.,Shieh, Wen-Chung,Du, Zhengming,Vargas, Kevin,Ciszewski, Lech,Lu, Yansong,Girgis, Michael,Lin, Melissa,Prashad, Mahavir
experimental part, p. 9067 - 9074 (2010/02/28)
A scalable synthetic strategy of a chiral, trisubstituted imidazolidinone (1), a novel cannabinoid-1 antagonist, starting from a commercially available mandelic acid (5) is described. The key step involves a regio- and stereoselective ring-opening of an a
