1198340-27-0Relevant academic research and scientific papers
Cs2CO3-promoted vinylation of phenols with trichloroethylene: Facile synthesis of (E)-1,2-dichloro-1-phenoxyethenes
Takahashi, Kazunori,Mamiya, Naho,Fukushima, Kei,Tsubuki, Masayoshi,Honda, Toshio
, p. 1622 - 1630 (2018/10/04)
An efficient method for the synthesis of (E)-1,2-dichloro-1-phenoxyethenes 2 has been developed. The reaction of phenol derivatives 1 with trichloroethylene at ambient temperature by means of Cs2CO3-DMSO system furnished the correspo
DIARYLETHENE COMPOUNDS AND USES THEREOF
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Paragraph 0196; 0439, (2014/09/29)
A compound according to Formula IA and IB, reversibly convertible under photochromic and electrochromic conditions between a ring-open isomer A and a ring-closed isomer B is provided. For substitutent groups, Z is N, O or S; each R1 is independently selected from the group consisting of H, or halo; each R2 is independently selected from the group consisting of H, halo, a polymer backbone, alkyl or aryl; or, when both R2 together form —CH═CH— and form part of a polymer backbone; each R3 is independently selected from the group consisting of H, halo, alkyl, alkoxy, thioalkyl or aryl; each R4 is aryl; and each R5 is independently selected from the group consisting of H, halo, alkyl, alkoxy, thioalkyl or aryl.
2-substituted benzo[b]furans from (E)-1,2-dichlorovinyl ethers and organoboron reagents: Scope and mechanistic investigations into the one-pot Suzuki coupling/direct arylation
Geary, Laina M.,Hultin, Philip G.
supporting information; experimental part, p. 5563 - 5573 (2010/12/29)
2-Substituted benzo[b]furans can easily be assembled from simple phenols, boronic acids or other organoboron reagents, and trichloroethylene. The overall process requires only two synthetic steps, with the key step being a one-pot sequential Suzuki cross-coupling/direct arylation reaction. The method tolerates many useful functional groups and does not require the installation of any other activating functionality. The modular nature of the process permits the rapid synthesis of many analogues using essentially the same chemistry, of particular value in drug development. Results of kinetic isotope effect studies and investigations into the regioselectivity of the process indicate that the direct arylation step most likely does not involve an electrophilic palladation. The most likely mechanism lies somewhere on the continuum between a C-H bond metathesis and an assisted palladation or concerted metallation-deprotonation pathway. A very efficient modular approach to the construction of benzo[b]furans using trichloroethylene as a scaffold is described. This method gives easy access to highlysubstituted heterocycles in only two synthetic operations, and is especially suitable for rapid construction of compound libraries.
Modular construction of 2-substituted benzo[b]furans from 1,2-Dichlorovinyl ethers
Geary, Laina M.,Hultin, Philip G.
supporting information; experimental part, p. 5478 - 5481 (2010/02/27)
"Chemical Equation Presented" (E)-1,2-Dichlorovinyl ethers and amides are easily accessible from trichloroethylene via nucleophilic addition across in situ synthesized dlchloroacetylene. A one-pot, sequential Suzukl-Miyaura coupling/intramolecular direct
