1198352-87-2

Upstream product

• 134653-70-6 ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate 
• 5446-16-2 (5-chloro-2-methoxyphenyl)hydrazine hydrochloride 

Downstream Products

• 1198352-88-3 1-(5-chloro-2-methoxyphenyl)-5-methyl-1H-pyrazole-4-carbohydrazide 
• 1422386-70-6 1-(5-chloro-2-hydroxyphenyl)-5-methyl-1H-pyrazole-4-carboxylic acid 
• 1422386-72-8 C₁₃H₁₃ClN₂O₃ 

Relevant academic research and scientific papers

NOVEL MACROCYCLES AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (Ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Synthesis, characterization and antibacterial activity of 2-[1-(5-chloro-2-methoxy-phenyl)-5-methyl-1H-pyrazol-4-yl]-5-(substituted-phenyl)-[1,3,4]oxadiazoles

In the present investigation a series of novel 2-[1-(5-chloro-2-methoxy-phenyl)-5-methyl-1H-pyrazol-4-yl]-5-(substituted-phenyl)-[1,3,4]oxadiazoles (4a-j) were synthesized by cyclization of substituted-benzoic acid N′-[1-(5-chloro-2-methoxy-phenyl)-5-meth