1198355-38-2Relevant academic research and scientific papers
Analogs of a 4-aminothieno[2,3-d]pyrimidine lead (QB13) as modulators of P-glycoprotein substrate specificity
Haecker, Hans-Georg,Haye, Antje de la,Sterz, Katja,Schnakenburg, Gregor,Wiese, Michael,Guetschow, Michael
supporting information; experimental part, p. 6102 - 6105 (2010/06/19)
P-glycoprotein (P-gp) is an important factor in the development of multidrug resistance (MDR) in cancer cells. In literature reports, a thieno[2,3-d]pyrimidine (QB13) was described as P-gp modulator and opposed effects on the cell accumulation of distinct
