1198364-45-2

Basic information

• Product Name: C₃₃H₄₂N₂O₄
• CAS NO: 1198364-45-2
• Molecular Weight: 530.707
• Mol File: 1198364-45-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₃H₄₂N₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₄₂N₂O₄(1198364-45-2)
• EPA Substance Registry System: C₃₃H₄₂N₂O₄(1198364-45-2)

Safety Data

• Hazardous Substances Data: 1198364-45-2(Hazardous Substances Data)

Upstream product

• 126378-43-6 (1R,2S,5R)-(-)-8-phenylmenthyl chloroformate 
• 4787-24-0 methyl 4-(4,9-dihydro-3H-pyrido[3,4-b]indol-1-yl)butanoate 

Relevant articles and documents

Palladium asymmetric reduction of β-carboline imines mediated by chiral auxiliaries assisted by microwave irradiation

An alternative synthetic approach for the introduction of chirality in β-carboline moiety through in situ reduction of N-acyliminium ion intermediates generated from imine 2 and chloroformate of 8-phenylmenthyl as chiral auxiliary was achieved. The method applied microwave-assisted irradiation and used PdCl2/Et3SiH protocol as a mild reducing agent, which decreased reaction times to minutes when compared to the conventional thermal reactions. The diastereoselectivity (4-12:1) of the reduction produced R-amines, which were assigned after chiral auxiliary removal and spectroscopic data compared to products obtained from Noyori asymmetric hydrogenation catalyst.