1198409-99-2Relevant academic research and scientific papers
Diverse Oxidative C(sp2)-N Bond Cleavages of Aromatic Fused Imidazoles for Synthesis of α-Ketoamides and N-(pyridin-2-yl)arylamides
Xu, Fangzhou,Wang, Yanyan,Xun, Xiwei,Huang, Yun,Jin, Zhichao,Song, Baoan,Wu, Jian
, p. 8411 - 8422 (2019/05/17)
An efficient and chemoselective C(sp2)-N bond cleavage of aromatic imidazo[1,2-a]pyridine molecules is developed. A broad scope of amide compounds such as α-ketoamides and N-(pyridin-2-yl)arylamides are afforded as the final products in up to quantitative yields. Diverse C-N bond cleavages are controlled by the oxidative species used in this transformation, with various amide products afforded in a chemoselective fashion. A preliminary study indicated that some α-ketoamides exhibit anti-Tobacco Mosaic Virus activity for potential use in plant protection.
Mild and efficient microwave-assisted reusable green CuO nanoparticles catalyzed Groebke-Blackburn-Bienayme reaction
Dandia, Anshu,Khan, Shahnawaz,Parewa, Vijay,Sharma, Amit,Kumawat, Begraj,Rathore, Kuldeep S.
, p. 429 - 438 (2019/01/21)
A convenient, fast and mild protocol for the synthesis of imidazo-fused polyheterocycles via microwave-assisted Groebke-Blackburn-Bienayme reaction catalyzed by CuO NPs has been described. This is the first report of using CuO NPs as green catalyst for th
Skeletal diverse synthesis of N-fused polycyclic heterocycles via the sequence of Ugi-type MCR and CuI-catalyzed coupling/tandem Pictet-Spengler reaction
Tyagi, Vikas,Khan, Shahnawaz,Bajpai, Vikas,Gauniyal, Harsh M.,Kumar, Brijesh,Chauhan, Prem M. S.
experimental part, p. 1414 - 1421 (2012/03/11)
Several diversity-oriented syntheses of N-fused polycyclic heterocycles have been demonstrated but most of them are based on point diversity within the same library and usually involve time-consuming sequential multistep syntheses, which also suffer from
Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors
Bode, Moira L.,Gravestock, David,Moleele, Simon S.,Van Der Westhuyzen, Christiaan W.,Pelly, Stephen C.,Steenkamp, Paul A.,Hoppe, Heinrich C.,Khan, Tasmiyah,Nkabinde, Lindiwe A.
experimental part, p. 4227 - 4237 (2011/08/21)
During random screening of a small in-house library of compounds, certain substituted imidazo[1,2-a]pyridines were found to be weak allosteric inhibitors of HIV-1 reverse transcriptase (RT). A library of these compounds was prepared using the Groebke reaction and a subset of compounds prepared from 2-chlorobenzaldehyde, cyclohexyl isocyanide and a 6-substituted 2-aminopyridine showed good inhibitory activity in enzymatic (RT) and HIV anti-infectivity MAGI whole cell assays. The compound showing the best anti-HIV-1 IIIB whole cell activity (MAGI IC50 = 0.18 μM, IC90 = 1.06 μM), along with a good selectivity index (>800), was 2-(2-chlorophenyl)-3- (cyclohexylamino)imidazo[1,2-a]pyridine-5-carbonitrile 38.
IMIDAZOPYRIDINES AND IMIDAZOPYRIMIDINES AS HIV-I REVERSE TRANSCRIPTASE INHIBITORS
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Page/Page column 15, (2010/04/25)
The invention provides compounds of formula A or B which are useful in the treatment of a subject infected with HIV.
A highly flexible and efficient ugi-type multicomponent synthesis of versatile n-fused aminoimidazoles
Guchhait, Sankar K.,Madaan, Chetna,Thakkar, Balmukund S.
experimental part, p. 3293 - 3300 (2010/02/28)
A microwave-promoted highly flexible and efficient Ugi-type multicomponent reaction of heterocyclic amidines with aldehydes and isocyanides catalyzed by zirconium(IV) chloride was developed. The general protocol offered the very reliable synthesis of a li
