1198413-03-4

Basic information

• Product Name: 9-Chloro-pyrido[1,2-a]pyriMidin-4-one
• Synonyms: 9-Chloro-pyrido[1,2-a]pyriMidin-4-one;9-chloro-4H-pyrido[1,2-a]pyrimidin-4-one
• CAS NO: 1198413-03-4
• Molecular Formula: C₈H₅ClN₂O
• Molecular Weight: 180.5911
• Mol File: 1198413-03-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 9-Chloro-pyrido[1,2-a]pyriMidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 9-Chloro-pyrido[1,2-a]pyriMidin-4-one(1198413-03-4)
• EPA Substance Registry System: 9-Chloro-pyrido[1,2-a]pyriMidin-4-one(1198413-03-4)

Safety Data

• Hazardous Substances Data: 1198413-03-4(Hazardous Substances Data)

Upstream product

• 1198412-81-5 C₁₂H₁₁ClN₂O₄ 

Downstream Products

• 1335239-77-4 9-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one 

Relevant articles and documents

Synthesis of halogenated 4H-pyrido[1,2-a]pyrimidin-4-ones

Halogenated 4H-pyrido[l,2-a]pyrimidin-4-one were synthesized by thermal cyclization and decarboxylation of isopropylidene (2-pyridylamino)methylenemalonates, prepared from 2-aminopyridines and isopropylidene methoxymethylenemalonate formed in situ. Instead of 4H-pyrido[l,2-a]pyrimidin-4-ones, the 6-chloro and 6-bromo derivatives afforded mixtures of 7-halo-l,4-dihydro-l,8-naphthyridin-4-ones and 1-(6-halo-2-pyridyl)-3-[(6-halo-2-pyridylamino)methylene]-1,2,3,4-tetrahydropyridine-2,4-diones. The latters formed from N-(2-pyridyl)iminoketenes, the common intermediates of 4H-pyrido[l,2-a]pyrimidin-4-one and l,8-naphthyridin-4-ones, via a "head-to-tail" [4+2] cycloaddition. 3-Halo-4H-pyrido[l,2-a]pyrimidin-4-ones were obtained from 4H-pyrido[1,2-a]pyrimidin-4-one with N-halosuccinimides. The structures of the new compounds were characterized by means of 1H NMR and 13C NMR examinations.