1198575-44-8

Upstream product

• 1192-62-7 1-(2-furyl)-1-ethanone 
• 501-65-5 diphenyl acetylene 
• 1536278-04-2 C₈H₁₀N₂O 
• 68727-98-0 N'-(1-(furan-2-yl)ethylidene)-4-methylbenzenesulfonohydrazide 
• 5007-50-1 1-(2-furyl)ethanone oxime 

Relevant academic research and scientific papers

Rhodium(III)-catalyzed vinylic C-H activation: A direct route toward pyridinium salts

A synthetic method for highly substituted pyridinium salts from the multicomponent reaction of vinyl ketones/aldehydes, amines, and alkynes using a rhodium catalyst is demonstrated. The catalytic reaction proceeds via an in situ generated imine-assisted RhIII-catalyzed vinylic C-H activation.

Rhodium-Catalyzed One-Pot Access to N-Polycyclic Aromatic Hydrocarbons from Aryl Ketones through Triple C-H Bond Activations

A Rh-catalyzed pot and step economic synthesis of aza-polycyclic aromatic hydrocarbons (N-PAHs) from readily available aryl ketones and alkynes has been disclosed. Additionally, a novel synthetic application of the well-known aminating reagent hydroxylamine-O-sulfonic acid (HOSA) has been explored as an in situ redox-neutral directing group for the formation of N-PAHs via isoquinoline. Multiple bond formation in a single operation through a cascade of triple C-H bond activations is the beauty of this protocol. The challenging annulations of two different alkynes in a regioselective fashion have been demonstrated effectively. Mechanistic studies reveal that 3,4-diphenyl-1-methylisoquinoline is an active intermediate for this one-pot transformation.

N-Tosylhydrazone directed annulation via C-H/N-N bond activation in Ru(ii)/PEG-400 as homogeneous recyclable catalytic system: a green synthesis of isoquinolines

A green and sustainable methodology for the synthesis of isoquinolines using Ru(ii)/PEG-400 as a homogeneous recyclable catalytic system has been demonstrated. N-Tosylhydrazone, a rarely explored directing group, has been successfully employed for an annu

Rhodium-catalyzed synthesis of isoquinolines and indenes from benzylidenehydrazones and internal alkynes

A new route is presented for the selective assembly of isoquinolines and indenes by rhodium-catalyzed tandem cyclization of benzylidenehydrazones with internal alkynes. This method involves the selective cleavage of the N-N bond and the C=N bonds and is dependent on the substituents of the benzylidenehydrazone.

Synthesis of isoquinolines and heterocycle-fused pyridines via three-component cascade reaction of aryl ketones, hydroxylamine, and alkynes

An efficient one-pot synthesis of isoquinolines and heterocycle-fused pyridines by three-component reaction of aryl ketones, hydroxylamine, and alkynes is developed. The reaction involves condensation of aryl ketones and hydroxylamine, rhodium(III)-cataly

Easy access to isoquinolines and tetrahydroquinolines from ketoximes and alkynes via rhodium-catalyzed C-H bond activation

(Chemical Equation Presented) Described herein is a convenient and highly regioselective synthesis of substituted isoquinoline derivatives from various aromatic ketoximes and alkynes via a one-pot, rhodium-catalyzed C-H bond activation. In addition, tetra