119858-52-5 Usage
Description
2-Methylimidazo[1,2-a]pyridine-8-amine, also known as 8-Aminomyrtilline, is a heterocyclic amine compound that is formed during the cooking or grilling of meat, especially at high temperatures. It is classified as a potential carcinogen due to its association with an increased risk of certain types of cancer.
Uses
Used in Cancer Research:
2-Methylimidazo[1,2-a]pyridine-8-amine is used as a research compound for studying the effects of heterocyclic amines on human health. It helps scientists understand the mechanisms by which these compounds may contribute to the development of cancer, particularly colorectal, breast, and prostate cancers.
Used in Public Health Education:
2-Methylimidazo[1,2-a]pyridine-8-amine is used as a reference point in public health campaigns and educational materials to raise awareness about the potential risks associated with consuming meat cooked at high temperatures. This information is crucial for promoting healthier cooking practices and reducing exposure to potentially harmful chemicals.
Used in Food Safety Regulations:
2-Methylimidazo[1,2-a]pyridine-8-amine is used as a benchmark in food safety regulations to set limits on the acceptable levels of heterocyclic amines in cooked meat products. This helps ensure that the consumption of these products does not pose an undue risk to public health.
Used in Cooking Technique Improvement:
2-Methylimidazo[1,2-a]pyridine-8-amine is used as a motivation for developing and promoting alternative cooking methods that minimize the formation of heterocyclic amines, such as marinating meat, using lower cooking temperatures, or incorporating antioxidants into recipes. These techniques can help reduce the potential health risks associated with consuming cooked meat.
Check Digit Verification of cas no
The CAS Registry Mumber 119858-52-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,8,5 and 8 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 119858-52:
(8*1)+(7*1)+(6*9)+(5*8)+(4*5)+(3*8)+(2*5)+(1*2)=165
165 % 10 = 5
So 119858-52-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H9N3/c1-6-5-11-4-2-3-7(9)8(11)10-6/h2-5H,9H2,1H3
119858-52-5Relevant articles and documents
Imidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its replacement by a pyridinone ring produces intriguing differences in cytocidal activity
Masurier, Nicolas,Debiton, Eric,Jacquemet, Alicia,Bussière, Antoine,Chezal, Jean-Michel,Ollivier, Anthony,Tétégan, Daté,Andaloussi, Mounir,Galmier, Marie-Joseph,Lacroix, Jacques,Canitrot, Damien,Teulade, Jean-Claude,Gaudreault, René C.,Chavignon, Olivier,Moreau, Emmanuel
experimental part, p. 137 - 150 (2012/07/16)
We recently discovered that five- and pseudo-five-fused-ring derivatives in an imidazonaphthyridine series were promising hit compounds for the development of new DNA-intercalators. In this study, novel (dihydro)imidazo[1,6] and [1,7]naphthyridi(no)nes were prepared including pseudo-pentacycles. All the compounds synthesized were screened against four tumor cell lines. Compounds 3(b-d) showed significant in vitro cytotoxicity, and DNA intercalation properties were demonstrated at 25 μM. Imidazonaphthyridinones exhibited no DNA binding affinity despite significant growth inhibition activity. Interestingly, when a pyridinone pharmacophore was linked to the imidazo[1,2-a]pyridine scaffold, the geometric orientation of the link had a strong impact on the growth inhibition activity. From these results we conclude that the moderate cytotoxicity observed for these compounds is independent of their DNA-binding and topoisomerase inhibition activities.
