1198596-72-3Relevant academic research and scientific papers
Synthesis of the carbon skeleton of the griseorhodins
Atkinson, Darcy J.,Furkert, Daniel P.,Brimble, Margaret A.
, p. 91 - 101 (2015/02/02)
A synthetic strategy to access the carbon skeleton of the griseorhodin family of natural products has been developed. The key step involved the acid-mediated spirocyclisation of a highly functionalised dihydroxyketone. The delicate electronic balance betw
An efficient formal synthesis of the human telomerase inhibitor (±)-γ-rubromycin
Rathwell, Dominea C. K.,Yang, Sung-Hyun,Tsang, Kit Y.,Brimble, Margaret A.
scheme or table, p. 7996 - 8000 (2010/01/16)
Balancing act: The correct balance of electronic factors in the naphthazarin and isocoumarin fragments facilitates the acid-mediated spiroketalization step to afford the key densely functionalized spiroketal (see picture; EOM=ethoxymethyl) in the formal s
