119860-59-2

Basic information

• Product Name: N-(Benzyloxycarbonyl)-2(S)-amino-3-cyclohexylpropionic acid
• Synonyms: N-(Benzyloxycarbonyl)-2(S)-amino-3-cyclohexylpropionic acid
• CAS NO: 119860-59-2
• Molecular Weight: 305.374
• Mol File: 119860-59-2.mol

Chemical Properties

• CAS DataBase Reference: N-(Benzyloxycarbonyl)-2(S)-amino-3-cyclohexylpropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-(Benzyloxycarbonyl)-2(S)-amino-3-cyclohexylpropionic acid(119860-59-2)
• EPA Substance Registry System: N-(Benzyloxycarbonyl)-2(S)-amino-3-cyclohexylpropionic acid(119860-59-2)

Safety Data

• Hazardous Substances Data: 119860-59-2(Hazardous Substances Data)

Upstream product

• 4441-50-3 β-cyclohexylalanine 
• 501-53-1 benzyl chloroformate 
• 1885-14-9 phenyl chloroformate 
• 99065-30-2 2-amino-3-cyclohexylpropionic acid hydrochloride 
• 204922-64-5 2-Benzyloxycarbonylamino-3-(1-nitro-cyclohexyl)-propionic acid methyl ester 
• 142035-71-0 2-Benzyloxycarbonylamino-3-cyclohexyl-propionic acid methyl ester 

Downstream Products

• 4441-50-3 β-cyclohexylalanine 
• 866235-10-1 2-benzyloxycarbonylamino-3-cyclohexyl-propionic acid 2,2,2-trifluoro-ethyl ester 
• 113828-93-6 (S)-2-Benzyloxycarbonylamino-3-cyclohexyl-propionic acid methyl ester 

Relevant articles and documents

Resolution of non-protein amino acids via Carica papaya lipase-catalyzed enantioselective transesterification

Carica papaya lipase-catalyzed transesterification of the 2,2,2-trifluoroethyl esters of N-benzyloxycarbonylated dl-amino acids carrying aliphatic side chains proceeded smoothly and, in almost all the cases, enantiospecifically (E = >200), affording the l-methyl esters and leaving the d-trifluoroethyl esters intact.

New synthetic routes to α-amino acids and γ-oxygenated α-amino acids. Reductive denitration and oxidative transformations of γ-nitro-α-amino acids

Transformation of γ-nitro-α-amino acid derivatives into α-amino acids by reductive denitration, into the γ-oxo-α-amino acids by ozonolysis of the corresponding amino acid ester nitronate derivatives, and into γ-hydroxy-α-amino acid derivatives by subsequent reduction of the oxo functionality, can be achieved in good yields. As the γ-nitro-α-amino acid derivatives are prepared from N,O-protected dehydroalanines derivable from the corresponding alanine, serine and cysteine derivatives by specific routes, the overall procedures provide a means for selective conversion of these simple α-amino acids into more complex ones.

ANALOG OF PEPTIDASE SUBSTRATES

This invention relates to novel analogs of certain peptidase substrates in which the nitrogen atom of the scissile amide bond has been replaced with a difluoromethylene moiety and in which the carbonyl moiety of its adjacent amide bond has been replaced w

Novel peptidase inhibitors

This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide bond of a partial retropeptide analog of the substrate has been replaced by a difluoromethylene moiety. These peptidase substrate analogs provide specific enzyme inhibitors for a variety of proteases, the inhibition of which exert valuable pharmacological activities and therefore have useful physiological consequences in a variety of disease states.

Novel peptidase inhibitors

This invention relates to activated electrophilic ketone retroamide analogs of certain peptidase substrates having the formula R1NHCHR2COCF2CHR3(NRbCOXRa)nQ These compounds are useful in inhibiting serine-, thiol-, carboxylic acid- and metallo- dependent