1198615-84-7

Basic information

• Product Name: Ethyl 3-(2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate
• Synonyms: Ethyl 3-(2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate
• CAS NO: 1198615-84-7
• Molecular Formula: C₁₇H₂₅BO₄
• Molecular Weight: 304.189
• Mol File: 1198615-84-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethyl 3-(2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 3-(2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate(1198615-84-7)
• EPA Substance Registry System: Ethyl 3-(2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate(1198615-84-7)

Safety Data

• Hazardous Substances Data: 1198615-84-7(Hazardous Substances Data)

Usage

Uses

Ethyl 3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate acts as a reagent in the preparation of N-(3-amino-2-hydroxypropyl)benzenesulfonamide and N-(3-amino-2-hydroxypropyl)thiophenesulfonamide derivatives as calcium-sensing receptor antagonists and parathyroid hormone (PTH) secretion promoters

Upstream product

• 135613-33-1 3-(2-bromophey)propionic acid ethyl ester 
• 73183-34-3 bis(pinacol)diborane 
• 15115-58-9 3-(2-bromophenyl)propionic acid 

Downstream Products

• 1347747-14-1 C₂₇H₂₄F₃NO₄ 

Relevant articles and documents

Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis

Biphenylacetic acid (5) was identified through a library screen as an inhibitor of the prostaglandin D2 receptor DP2 (CRTH2). Optimization for potency and pharmacokinetic properties led to a series of selective CRTH2 antagonists. Compounds demonstrated potency in a human DP2 binding assay and a human whole blood eosinophil shape change assay, as well as good oral bioavailability in rat and dog, and efficacy in a mouse model of allergic rhinitis following oral dosing.